Synthesis and photophysicochemical properties of zinc phthalocyanine derivatized with benzothiazole or carbazole photosensitizers

Synthesis of alkylthio substituted pyridoporphyrazines and their photophysicochemical properties

“…The F D of compound 5 was estimated to be 0.43, which had a lower value than the standard zinc phthalocyanine (0.64, Table 2). The F D value is considered to be sufficient to utilize as a photosensitizer for PDT [5,8]. A similar observation was obtained for compound 6.…”

“…Phthalocyanines and their related compounds are particularly known to have potential as photosensitizers of photodynamic therapy of cancer (PDT) [2,[4][5][6][7][8]. Phthalocyanines and their related compounds used for PDT are required to have long life-time triplet states and show strong absorption of far red light between 600 and 800 nm, values of wavelengths which have a greater penetration of tissue and satisfactory photosensitization of singlet oxygen [2].…”

“…The strongest absorption maxima of phthalocyanines and their related compounds in visible region called the Q band can be moved by bathochromic effect to introduce an electron-donating substituent at a non-peripheral (1,4,8,11,15,18,22,25) position. For PDT photosensitizers, the absorption maxima of phthalo cyanines and their related compounds are best when moved to the nearinfrared region [2,9].…”

Synthesis and Isolation of 2,9,17,23-Tetrakis[(3,5-dimethyl-1H-pyrazol-1-yl)phenoxy]phthalocyanine and Its Magnesium(II) and Zinc(II) Complexes

“…[17][18][19][20][21][22][23][24][25][26][27] These substituted phthalocyanines can be highly efficient photosensitizers of singlet oxygen due to dual or synergistic therapeutic effect. [28,29] However, only a few works devoted to phthalocyanines [30][31][32] and porphyrin [33] containing pyrazole substituents are known. Interest to such substituents is caused by various biological activity of the pyrazole derivatives (antimicrobial, [34] antipyretic, [35] analgesic, [36] anti-inflammatory, [37] antiviral [38] and other properties [39] ).…”

Synthesis, Characterization, Photophysical and Photochemical Properties of Novel Phthalocyanines

“…[18][19][20] There are some studies in the literature which reported photosensiter properties of different phthalocyanines containing benzothiazole groups. [21,22] But in this paper, it was planned to prepare novel non-peripherally benzothiazole substituted phthalocyanines as photosensitizer compounds which can have potential for PDT apllications. To improve the pharmacological properties of photosensitizers benzothiazole groups were attached to the non-peripherally substitution positions of phthalocyanine ring.…”