Synthesis and physicochemical characterization of chemically modified chitosan by succinic anhydride

Mello, Karine Gargioni Pereira Correa de; Bernusso, Leandra de Cássia; Pitombo, Ronaldo Nogueira de Moraes; Polakiewicz, Bronislaw

doi:10.1590/s1516-89132006000500017

Cited by 27 publications

(22 citation statements)

References 7 publications

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“…Já a porção interna, é mais espessa e é formada por camadas de quitina, carbonato de cálcio e pigmentos. A quitina por ser rígida e impermeável, proporciona sustentação, proteção mecânica e ainda atua contra a desidratação (MELLO, 2006).…”

Section: Polímerosunclassified

“…Com o objetivo de determinar o grau de desacetilação da quitosana muitos métodos analíticos têm sido propostos, como: espectroscopia na região do infravermelho (IV), titulometria com ninhidrina e ressonância nuclear magnética (RMN) (MELLO et al, 2006).…”

Section: Grau De Desacetilação (Gd)unclassified

“…As equações propostas, normalmente, utilizam os valores de absorbância das bandas em 1655 e 3450 cm -1 , associadas a carbonila e hidroxila, respectivamente. A primeira banda varia de acordo com o grau de desacetilação da quitina, diminuindo da quitina para a quitosana, e a segunda, está presente tanto no espectro da quitina quanto no da quitosana, então, não sofre alteração (MUZZARELLI, 1985;KIM et al, 1997;NO;MEYERS, 1998;MUZZARELLI, 1998;MONTEIRO, 2000;MELLO et al, 2006). …”

Section: Grau De Desacetilação (Gd)unclassified

“…O método utilizado na síntese de 2-carboxibenzamido-quitosana também foi a descrita por Mello, 2006. A quitosana foi suspensa na água, agitou-se e depois foi adicionado o ácido acético. Agitou-se o meio até completa solubilização da quitosana.…”

Section: Síntese Química De 2-carboxibenzamido-quitosanaunclassified

“…As freqüências absorvidas pela amostra serão evidenciadas pela diferença entre os eixos. O espectrômetro registra os resultados na forma de gráfico, mostrando a absorbância versus a freqüência ou comprimento de onda (MUZZARELLI, 1985;KIM et al, 1997;NO;MEYERS, 1998;MUZZARELLI, 1998;MONTEIRO, 2000;MELLO et al, 2006 …”

Section: Análises De Espectroscopia Infravermelho (Iv)unclassified

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Síntese e avaliações físico-químicas e biológicas de derivados de quitosana de alta e baixa massa molecular

Bezerra¹

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Section: Polímerosunclassified

Section: Grau De Desacetilação (Gd)unclassified

Section: Síntese Química De 2-carboxibenzamido-quitosanaunclassified

Section: Análises De Espectroscopia Infravermelho (Iv)unclassified

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Síntese e avaliações físico-químicas e biológicas de derivados de quitosana de alta e baixa massa molecular

Bezerra¹

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Cytocompatible Fluorescent Quantum Dot/PEG‐Chitosan Bioconjugates for Nanomedicine Applications

et al. 2015

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In this study, novel nanobioconjugates based on quantum dots and a PEGylated chitosan derivative (PEG‐CHI) have been designed and synthesised by a single‐step aqueous route at room temperature. Chitosan was chemically modified by PEGylation aiming to significantly improve its water solubility and used as the capping ligand in the preparation of CdS quantum dot (QD) colloidal systems. UV/Vis and photoluminescence spectroscopy, transmission electron microscopy, dynamic light scattering, and the zeta potential were used to characterise the biopolymer‐capped semi‐conductor nanocrystals and their relative stability. The results clearly demonstrated that the PEG‐CHI derivative is remarkably effective in nucleating and stabilising ultra‐small colloidal CdS QDs in aqueous suspensions under acidic, neutral and alkaline media with an average size of approximately 2.0–3.0 nm and simultaneously showing luminescent activity in the visible range. In addition, the results of cell viability analysis in vitro using two cell cultures based on MTT bioassays demonstrated no cytotoxicity of the CdS QD/PEG‐chitosan bioconjugates. Thus, based on these findings, it can be envisioned that these bioconjugates have potential use as biocompatible fluorescent biomarkers for nanomedicine applications.

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Acidic pH resistance of grafted chitosan on dental implant

et al. 2014

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Over the last decade, access to dental care has increasingly become a service requested by the population, especially in the case of dental implants. However, the major cause of implant failure is an inflammatory disease: peri-implantitis. Currently, the adhesion strength of antibacterial coatings at implant surfaces remains a problem to solve. In order to propose a functionalized implant with a resistant antibacterial coating, a novel method of chitosan immobilization at implant surface has been investigated. Functionalization of the pre-active titanium (Ti) surface was performed using triethoxysilylpropyl succinic anhydride (TESPSA) as a coupling agent which forms a stable double peptide bond with chitosan. The chitosan presence and the chemical resistibility of the coating under acid pH solutions (pH 5 and pH 3) were confirmed by FTIR-ATR and XPS analyses. Furthermore, peel test results showed high adhesive resistance of the TESPSA/chitosan coating at the substrate. Cytocompatibility was evaluated by cell morphology with confocal imaging. Images showed healthy morphology of human gingival fibroblasts (HGF-1). Finally, the reported method for chitosan immobilization on Ti surface via peptide bindings allows for the improvement of its adhesive capacities and resistibility while maintaining its cytocompatibility. Surface functionalization using the TESPSA/chitosan coupling method is noncytotoxic and stable even in drastic environments as found in oral cavity, thus making it a valuable candidate for clinical implantology applications.

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Synthesis and physicochemical characterization of chemically modified chitosan by succinic anhydride

Abstract: The N-succinil-chitosan is a chemically modified derivative of the biopolymer chitosan.

Cited by 27 publications

References 7 publications

Síntese e avaliações físico-químicas e biológicas de derivados de quitosana de alta e baixa massa molecular

Síntese e avaliações físico-químicas e biológicas de derivados de quitosana de alta e baixa massa molecular

Cytocompatible Fluorescent Quantum Dot/PEG‐Chitosan Bioconjugates for Nanomedicine Applications

Acidic pH resistance of grafted chitosan on dental implant

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