Synthesis and physicochemical characterization of nanocrystalline chitosan-containing calcium carbonate apatites

Ezhova, Zh. A.; Koval, E. M.; Zakharov, N. A.; Kalinnikov, V.T.

doi:10.1134/s0036023611060076

Cited by 7 publications

(1 citation statement)

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“…Hydroxyapatite is known to be very similar in composition to the inorganic component of bone tissue: the dry residue of bone tissue consists of 70% hydroxyapatite and 30% organic component of collagen. In addition to Са 2+ and PO 4 3- [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Doped calcium carbonate-phosphate used for bone tissue technology

Koroleva¹,

Dobrinskaya²,

Каманцев³

2017

Intergr Clin Med

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Doped with K + , Mg 2+ , Fe 2+ , Zn 2+ , Mn 2+ , Li + , Au 3+ , SiO 2 nanocrystalline calcium carbonate-phosphate extends significantly the functionality for drug delivery: it can be used to speed up the processes of bone repair and bone tissue strengthening. The advantage over other calcium phosphate biomaterials is strengthening of bone and tooth tissues of a human being of any age, the substances being transported through skin to restore broken bones in a critically short period of time regardless of age. The mechanical fracture strength of bone tissue increases almost in 5 times. These studies suggest doped calcium carbonate-phosphate is the most appropriate material, because reduce of the cholesterol rate in the blood in 2-2.5 time. The best results have been observed with concentrations of 5-10% doped calcium carbonatephosphate in the implant used the polycaprolactone. Young`s modulus is maximal for specimens with 5% doped calcium carbonate-phosphate.

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Section: Introductionmentioning

confidence: 99%

Doped calcium carbonate-phosphate used for bone tissue technology

Koroleva¹,

Dobrinskaya²,

Каманцев³

2017

Intergr Clin Med

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In situ ring-opening polymerization of hydroxyapatite/poly(ethylene adipate)-co-(ethylene terephthalate) biomimetic composites

Siriphannon

Monvisade

2013

Bull Mater Sci

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Hydroxyapatite/poly(ethylene adipate)-co-poly(ethylene terephthalate) biomaterials (HAp/PEA-co-PET) have been prepared by ring opening polymerization (ROP) of cyclic oligo(ethylene adipate)-co-oligo(ethylene terephthalate) (C-OEA-co-C-OET) in the porous hydroxyapatite (HAp) scaffolds at 250 • C for 24 h under vacuum. The content of ROP-PEA-co-PET in the HAp/PEA-co-PET composite was about 20 wt% with the values of number average molecular weight (M n) and weight average molecular weight (M W) of 3380 and 7160 g/mol, respectively. Compressive strength and modulus of the HAp/PEA-co-PET composites were about 29 and 246 MPa, respectively. These mechanical properties were higher than those of the porous HAp templates and natural cancellous bone. In vitro bioactivity of the HAp/PEA-co-PET composites was studied by soaking in simulated body fluid (SBF) under the flowing system at the rate of 130 mL/day for 7, 14, 21 and 28 days. The formation of hydroxyapatite nanocrystals was observed on the composite surfaces through the consumption of calcium and phosphorus from the SBF solution, indicating the bioactivity of these HAp/PEA-co-PET composites. These results indicated the competency of HAp/PEA-co-PET composites for biomedical applications.

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Preparation of Calcium Phosphate/Chitosan Granules

Голованова

2021

Inorg Mater

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Synthesis and physicochemical characterization of nanocrystalline chitosan-containing calcium carbonate apatites

Cited by 7 publications

References 1 publication

Doped calcium carbonate-phosphate used for bone tissue technology

Doped calcium carbonate-phosphate used for bone tissue technology

In situ ring-opening polymerization of hydroxyapatite/poly(ethylene adipate)-co-(ethylene terephthalate) biomimetic composites

Preparation of Calcium Phosphate/Chitosan Granules

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