Synthesis and potent antimicrobial activity of some novel methyl or ethyl 1H-benzimidazole-5-carboxylates derivatives carrying amide or amidine groups

NMR and NBO calculation of benzimidazoles and pyrimidines: Nano physical parameters investigation

“…E-mail: m_monajjemi@yahoo.com antiulcerative, anti-hypertensive, antiviral, antifungal, antitumor and antihistaminic agents, and antihelminthic agents in veterinary medicine (Spasov et al, 1999). Benzimidazole derivatives have found the appreciation in diverse therapeutic areas including antimicrobial activity Wu et al, 2003;Mollaamin et al, 2008;Ozden et al, 2005;Sztanke et al, 2006), the activity against several viruses such as HIV (Porcari et al ., 1998;Samia et al, 2006), antiallergic (Kilcig and Altanlar, 2006;Nakano et al, 1999), antioxidant, antihistaminic (Vijayakumar and Jafar Ahamed, 2010), antitubercular (Yadav and Srivastava, 2011;Kuchkguzel et al, 2001), antiasthmatic (Souness et al, 2000), antidiabetic (Senten et al, 2003;Black et al, 2005), anticancer (Pal et al, 2011;Sun et al, 2011;Kruse et al,1989;Islam et al,1991;Ramla et al,2007), antitumor (Denny et al, 1990 ;Tatsuta et al, 2005), antiulcer (Jung et al, 1993;Hazelton et al, 1995), antihelmentic (Karen, 2006), HIV-1 reverse transcriptase inhibitors (Gardiner et al, 2003), anticoagulant (Young et al, 2006), anti inflammatory (Fox et al, 2009), antibacterial (Rosowsky et al, 1997;Andrzejewska et al, 2004) , the series of biologically active benzimidazoles (AJafar et al,2009). Furthermore, these heterocycles are considered to be privileged structures by medicinal chemists.…”

Synthesis and potent antistaphylococcal activity of some new 2-[4-(3,4-dimethoxyphenoxy)phenyl]-1,N-disubstituted-1H-benzimidazole-5-carboxamidines

“…It is also well known that amides, amidines, and combinations of both are present in a variety of antimicrobial, antiparasitic, anthelmintic, antiviral, and antitumoral agents. Furthermore, our previous work [2][3][4] and that of others showed that benzimidazolecarboxamidines display good antibacterial and antimycotic activity. The literature survey reveals that one of the benzimidazolecarboxamidine having 3,4-(dimethoxy-phenoxy)-phenyl moiety (23, unpublished structural data) 5 was reported as an inhibitor of histidine protein kinase (HPK) from the bacterial two-component system (TCS) which are composed of a HPK and a response regulator (RR) for signal transduction.…”

“…Sodium bisulphite adduct of 4-(3,4-dimethoxy)phenoxybenzaldehyde (2) Compound 1 (1.94 g, 7.5 mmol) was dissolved in EtOH (25 mL) and sodium metabisulfite (0.8 g) (5 mL of water) was added in portions. The reaction mixture was stirred vigorously and more EtOH was added.…”

Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted benzo[h]quinazolines, benzo[h]quinolines and naphthaleno[d]thiazoles

“…Furthermore, the minimum inhibitory concentration (MIC) measurement (expressed in μg/mL) was determined for the most active compound X that showed significant growth inhibition zones using the two-fold serial dilution method [45].The diameter of inhibition zones of the screened compounds are recorded in table (1).…”