Synthesis and preliminary in vivo evaluations of polyurethane microstructures for transdermal drug delivery

Borcan, Florin; Şoica, Codruţa; Ganta, Srinivas; Amiji, Mansoor M.; Dehelean, Cristina; Munteanu, Melania

doi:10.1186/1752-153x-6-87

Cited by 17 publications

(16 citation statements)

References 32 publications

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“…Therefore, our aim was to synthesize PU for the purpose of drug delivery with the glycolized product of PET waste. PUs are one of the most captivating biodegradable polymers and show their novelty in biomedical applications . Several researchers have worked with PU systems for the sustained and controlled delivery of anticancer drugs, colon‐specific drugs, antifungal drugs, and anti‐inflammatory drugs .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of a novel pH‐sensitive polyurethane–alginate blend with poly(ethylene terephthalate) waste for the oral delivery of protein

Bhattacharyya

Mukhopadhyay

Kundu

2014

J of Applied Polymer Sci

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With the aim of using poly(ethylene terephthalate) (PET) waste for the synthesis of a value added product, we prepared polyurethane (PU) from bishydrohxyethylene terephthalate (BHET), a byproduct obtained from the glycolysis of PET. Biodegradable, waterswelling PU was synthesized by the reaction of BHET, hexamethylene diisocyanate, and poly(ethylene glycol) (PEG). Both BHET and PU were characterized by Fourier transform infrared spectroscopy, and the formation of PU was further confirmed by NMR analysis. The swelling behavior of PU in water was examined in terms of the various molecular weights of PEG. Semi-interpenetrating network beads of PU and sodium alginate were prepared with calcium chloride (CaCl 2 ) as a crosslinker to attain a pH sensitivity for successful oral protein/drug delivery. Bovine serum albumin (BSA) was used as a model protein. The pH-responsive swelling behavior and protein (BSA) release kinetics in different pH media corresponding to the gastrointestinal tract (pH 1.2 and 7.4) were investigated. The degree of swelling in the case of the PU-alginate beads at pH 1.2 was found to be at a minimum, whereas the degree of swelling was significantly elevated (1080%) at pH 7.4. This substantiated the pH sensitivity of the polymeric beads with a minimum loss of encapsulated protein in the stomach and the almost complete release of encapsulated protein in the intestine. This revealed good opportunities for oral protein/ drug delivery with a polymer derived from waste PET. Moreover, the fungal biodegradation study confirmed its compatibility with the ecological system.

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Section: Introductionmentioning

confidence: 99%

Synthesis of a novel pH‐sensitive polyurethane–alginate blend with poly(ethylene terephthalate) waste for the oral delivery of protein

Bhattacharyya

Mukhopadhyay

Kundu

2014

J of Applied Polymer Sci

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“…The influence of the aqueous components ratio [30], isocyanate component [31], and influence of stirring speed [32] were already studied by our team in order to optimize the structures sizes and stability.…”

Section: Methodsmentioning

confidence: 99%

“…PU structures synthesis procedure was already described in the literature [12,31] and involves the following steps:…”

Section: Methodsmentioning

confidence: 99%

Influence of emulsifiers on the characteristics of polyurethane structures used as drug carrier

Heghes

Şoica

Ardelean

et al. 2013

Chemistry Central Journal

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BackgroundEmulsifiers have a significant role in the emulsion polymerization by reducing the interfacial tension thus increasing the stability of colloidal dispersions of polymer nanostructures. This study evaluates the impact of four emulsifiers on the characteristics of polyurethane hollow structures used as drug delivery system.ResultsPolyurethane (PU) structures with high stability and sizes ranging from nano- to micro-scale were obtained by interfacial polyaddition combined with spontaneous emulsification. The pH of PU aqueous solutions (0.1% w/w) was slightly acidic, which is acceptable for products intended to be used on human skin. Agglomerated structures with irregular shapes were observed by scanning electron microscopy. The synthesized structures have melting points between 245-265°C and reveal promising results in different evaluations (TEWL, mexametry) on murine skin.ConclusionsIn this study hollow PU structures of reduced noxiousness were synthesized, their size and stability being influenced by emulsifiers. Such structures could be used in the pharmaceutical field as future drug delivery systems.

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“…The polyurethane structures were obtained following a protocolwhich was already described in scientific literature in our previous papers [7][8][9][10][11][12][13][14][15][16][17]: The 1 st step -The preparations of the two phases…”

Section: The Obtaining Of Samplesmentioning

confidence: 99%

Obtaining and Characterization of a Polyurethane Carrier Used for Eugenol as a Possible Remedy in Oral Therapies

Popa¹,

Rusu²,

Susan³

et al. 2018

Mat.Plast.

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The cloves are antiseptic, antiparasitic, antibacterial, antifungal, antiviral, anesthetic, analgesic, anti-inflammatory, tonic, carminative, anti-ulcer, antithrombotic, antioxidant and anti-cancerous. They contain eugenol, tannins and flavonoids that also help to strengthen the vein wall. This paper presents the obtaining and the characterization of a polyurethane drug delivery system which can be used for the transmembrane transport of eugenol in oral therapies. The products were analyzed by pH and solubility measurements, thermal decomposition and zetasizer tests and they were applied on mice skin to evaluate their harmfulness. The results suggest that were obtained neutral pH structures with low solubility and a good thermal stability, with sizes between 241 and 289 nm and no toxicity effect was found in the case of studied samples.

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Synthesis and preliminary in vivo evaluations of polyurethane microstructures for transdermal drug delivery

Cited by 17 publications

References 32 publications

Synthesis of a novel pH‐sensitive polyurethane–alginate blend with poly(ethylene terephthalate) waste for the oral delivery of protein

Synthesis of a novel pH‐sensitive polyurethane–alginate blend with poly(ethylene terephthalate) waste for the oral delivery of protein

Influence of emulsifiers on the characteristics of polyurethane structures used as drug carrier

Obtaining and Characterization of a Polyurethane Carrier Used for Eugenol as a Possible Remedy in Oral Therapies

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