2023
DOI: 10.3390/app132112002
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Synthesis and Preliminary Screening of the Biological Activity of Sulindac Sulfoximine Derivatives

Cosimo Cardellicchio,
Valentino Laquintana,
Rosa Maria Iacobazzi
et al.

Abstract: Sulindac is a well-known anti-inflammatory agent, sometimes employed as an adjuvant in antitumor therapy. Due to the recent interest in sulfoximine for its potential chemotherapeutics, we decided to transform sulindac and its methyl ester into the corresponding sulfoximines to test their antitumor activity. These compounds were fully characterized. Eventually, sulindac, sulindac methyl ester and the two novel corresponding sulfoximines were tested against malignant cells of U-87 glioblastoma, MCF-7 human breas… Show more

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