Synthesis and Preparation of Chitosan/Clay Microspheres: Effect of Process Parameters and Clay Type

Santos, Bárbara; Maciel, Matheus; Tavares, Albaniza Alves; Fernandes, Clarissa Q. B. de Araújo; Sousa, Wladymyr Jefferson Bacalhau de; Fook, Marcus Vinícius Lia; Leite, Itamara Farias; Silva, Suédina Maria de Lima

doi:10.3390/ma11122523

Cited by 13 publications

(6 citation statements)

References 58 publications

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“…The diffraction pattern of CS, as shown in Figure 6, exhibited two major crystalline peaks at 10.8 • and 20.0 • , which confirms the partial crystallinity of the polymer, in agreement with previously reported results [55][56][57][58]. These peaks (10.8 • and 20.0 • ) are typical fingerprints of chitosan related to hydrated and anhydrous crystals, respectively [56].…”

Section: Xrd Analysissupporting

confidence: 90%

The Impact of the Ionic Cross-Linking Mode on the Physical and In Vitro Dexamethasone Release Properties of Chitosan/Hydroxyapatite Beads

et al. 2019

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In this study, the effect of the ionic cross-linking mode on the ability to control physical properties and in vitro release behavior of the dexamethasone (DEX) drug from chitosan (CS) and chitosan/hydroxyapatite (CS/HA) beads was investigated. CS solutions without and with HA and DEX were dripped into two coagulation solutions, prepared with a non-toxic ionic crosslinker (sodium tripolyphosphate, TPP) and distilled water, one at pH = 9.0 and other at pH = 6.0. Optical microscopy (OM) and scanning electron microscopy (SEM) results showed changes on the surface topology of the beads, with a reduction of roughness for beads prepared at pH = 6.0 and an increase for the one prepared at pH = 9.0. The diameter and sphericity of the beads prepared at pH = 6.0 proved more uniform and had a larger pore size with a good interconnectivity framework. Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) suggested a higher crosslinking degree for beads prepared at pH = 6.0, corroborated by X-ray diffraction profiles (XRD) analysis that indicated a decrease in the crystalline structure for such beads. In in vitro drug release data, all beads presented a sustained release during the studied period (24 h). The drug release rate was affected by the pH of the coagulation solution used in the preparation of the beads. The in vitro kinetics of the release process was of the Peppas–Sahlin model, controlled by both diffusion and relaxation of polymer chains or swelling (anomalous transport mechanism). Our results suggest that DEX-loaded CS/HA beads, crosslinked in TPP coagulation solution at pH = 9.0, led to a decrease in the DEX release rate and prolonged the release period. Thus, this composition might have prospective as a functional material for bone and cartilage tissue engineering.

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Section: Xrd Analysissupporting

confidence: 90%

The Impact of the Ionic Cross-Linking Mode on the Physical and In Vitro Dexamethasone Release Properties of Chitosan/Hydroxyapatite Beads

et al. 2019

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“…It is evident that the microsphere diameter will in uence the structure. In meanwhile, we observed that tight external structures are produced on the surface of microspheres of CS in the studies [28,29] . The microsphere diameter may have an impact on the hemostatic effect.…”

Section: Introductionmentioning

confidence: 99%

The fabrication and hemostasis of controlled-size chitosan microspheres：A preliminary research

Zhou,

Wen,

Xia

et al. 2024

Preprint

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Extreme bleeding can make therapy challenging or even fatal. Even though several commercial homeostatic medicines have favorable clinical results, there is still a desire to discover materials that are effective, bio-safe, inexpensive, and simple to produce. In this study, regulated and uniformly sized chitosan microspheres (CSM) were fabricated using a simple process and assessed as hemostatic agents. In addition, the diameter criteria for optimal hemostatic effects were evaluated. Precipitation and coaxial airflow shear technique were used to fabricate CSM with a controlled and homogeneous particle size. Secondly, scanning electron microscope and N2 adsorption-desorption isotherm characterization, water absorption experiments, and in vitro coagulation evaluation demonstrated that the CSM produced in this experiment have a porous structure, a high specific surface area, and a high-water absorption capacity. The hemostatic effect was investigated using a rabbit blood coagulation experiment in vitro. To further examine the hemostatic effect using an arterial/venous bleeding model in rats. The results were superior to those in the blank control group. The hemostatic effect is related to the diameter of the microspheres. In these experiments, large diameter chitosan microspheres possessed superior hemostatic effect. Hence, these novel CSM show considerable potential for use in hemostatic events and demonstrated a diameter-dependent hemostatic effect.

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“…Numerous researchers and their coworkers have performed several trials for developing efficient adsorbents from chitosan by incorporating different substrates such as sand [16], perlite [17], ceramic alumina [18], oil palm ash [19], calcium alginate [20], magnetite [21], polyurethane [22], cotton fiber [23], cellulose [24], polyvinyl alcohol [25], polyvinyl chloride [13], etc. However, the major focus has been on clay minerals [5][6][7][26][27][28][29][30][31][32][33]. Clay minerals are attractive immobilization/support materials for chitosan owing to their relatively large available surface areas [34].…”

Section: Introductionmentioning

confidence: 99%

pH-Triggered Interfacial Interaction of Kaolinite/Chitosan Nanocomposites with Anionic Azo Dye

et al. 2019

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Advanced engineering of naturally occurring materials opens new doors in nanoscience and nanotechnology for the separation and/or removal of environmental hazards. Here, a series of nanocomposites containing kaolinite and chitosan varying in the range of 20 to 80% (w/w) kaolinite were used for the adsorptive removal of a reactive textile dye, Remazol Red, from an aqueous solution. Batch experiments were carried out to investigate the effects of pH, contact time, and initial dye concentration on the adsorption capacity. Nanocomposites containing 80% kaolinite (w/w) and 20% chitosan (w/w), i.e., NK80C20, showed an equilibrium adsorption capacity of 371.8 mg/g at pH 2.5, which was 5.2 times higher than that of commercial activated charcoal. Moreover, NK80C20 was regenerated instantly up to 99.9% at pH 10. Therefore, NK80C20 can be effectively utilized as a potential adsorbent for the separation of Remazol Red and homologous azo dyes from industrial effluents. We expect that the findings from this study will play a vital role in environmental research leading to advanced applications in water purification.

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Synthesis and Preparation of Chitosan/Clay Microspheres: Effect of Process Parameters and Clay Type

Cited by 13 publications

References 58 publications

The Impact of the Ionic Cross-Linking Mode on the Physical and In Vitro Dexamethasone Release Properties of Chitosan/Hydroxyapatite Beads

The Impact of the Ionic Cross-Linking Mode on the Physical and In Vitro Dexamethasone Release Properties of Chitosan/Hydroxyapatite Beads

The fabrication and hemostasis of controlled-size chitosan microspheres：A preliminary research

pH-Triggered Interfacial Interaction of Kaolinite/Chitosan Nanocomposites with Anionic Azo Dye

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