Synthesis and primary cytotoxicity evaluation of new 5-benzylidene-2,4-thiazolidinedione derivatives

Synthesis and Antidiabetic Evaluation of 5-(2-Methoxy-6-pentadecylbenzylidene)-3-alkyl/aryl substituted thiazolidine-2,4-dione Derivatives

“…The 13 C NMR of 6c is in accordance with the desired structure, the signals in the region 168.6, 166.4, 165.6 ppm is assigned to carbonyl signal of ethylester group and 2,4-thiazolidine dione ring, respectively. The remaining carbon signals of the aromatic and aliphatic groups were found to be in the expected region.…”

“…Compounds containing thiazolidinedione moiety have been found to demonstrate an extensive assortment of biological activities viz., COX-2 inhibitor [9], antihyperglycemic [10], anti-inflammatory [11], antioxidant [12], cytotoxic [13], antimicrobial [14], neuro-protective [15], antiproliferative [16], antitumor [17], MurD ligase inhibitor [18], monoamine oxidase B (MAO-B) inhibitor [19], antimalarial [20] and chemotherapeutic activities [21].…”

Synthesis and Protein Tyrosine Phosphatase 1B Inhibitory Activity of Novel Chalcone Derivatives Containing 3,4-Dihydroquinolin-2(1H)-one Moiety

“…很多来自 天然物的查尔酮已经被证实, 对 PTP1B 显示良好的抑 制作用 [14～16] . 此外, 3,4-二氢-2(1H)-喹啉酮结构也具有 优良的生物活性 [17] , 其环上的羰基及 N 原子可以参与 生物体中氢键的形成, 增加药物与受体的亲和力和选择 性 [18] . 1 结果与讨论 ( ( …”

Microwave-assisted synthesis and evaluation of N-substituted thiazolidine-2,4-dione derivatives as antimicrobial agents

“…Drugs with more advanced profile are the focus of attention. Besides, thiazolidine derivatives show anticancer [8], antiinflammatory [9], antiobesity [10], antifungal [11], antidiabetic [12], cardiotonic [13] and anticonvulsant [14] acivities. Multiplicity of biological activities along with antidiabetes has made the study of 2,4-thiazolidinediones interesting.…”