Synthesis and properties of 3-alkyl(aryl)-5-(dimethylaminomethyl)pyrazoles

Gadzhily, R. A.; Дикусар, Е. А.; Aliev, A. A.; Karaeva, A. R.; Nagieva, Sh. F.; Поткин, В. И.

doi:10.1134/s1070428015040120

Cited by 6 publications

(1 citation statement)

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“…1,3-disubstituted 5chloropyrazoles [11] were synthesized from 2,2-dichlorovinyl alkyl ketones and alkyl-or 1,1-dialkyl hydrazines, the reaction of 1alkyl(aryl)-3,4-bis(dimethylamino)but-2-en-1ones with hydrazine hydrate led to the preparation of 3-alkyl(aryl)-5-(dimethylaminomethyl) pyrazoles [12][13], etc.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Conversion of Pyrazole Derivatives

Karayeva¹

2019

Chemical Problems

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The new representatives of functionally substituted pyrazoles were synthesized and their interactions with secondary amines studied. It found that the interaction of 3,4-bis(diethylamino)but-2en-1-ones with hydrazine hydrate gave rise to 3-alkyl-5-(diethylaminomethyl)pyrazoles. Appropriate 1acetyl and 1-(2-chloromethyl carbonyl)pyrazoles were synthesized through the acylation of the last products with acetyl-and monochloroacetyl chloride in the presence of triethylamine. It revealed that 1-(2-chloromethyl carbonyl)pyrazoles react with twofold quantity of diethylamine and morpholine under mild reaction conditions to form new polyfunctional pyrazole derivatives. The composition and structure of the synthesized compounds were confirmed by IR-and NMR 1 Н-spectroscopy. It established that 3-methyl-and 3-ethyl-5-(diethylaminomethyl) pyrazoles were biologically active substances out of synthesized functionally pyrazole derivatives.

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Section: Introductionmentioning

confidence: 99%