SYNTHESIS AND PROPERTIES OF A SERIES OF 3-ALKYLTHIO DERIVATIVES 9-METHYLPYRAZOLO[1,5-d][1,2,4]TRIAZOLO[3,4-f][1,2,4]TRIAZINE

Fedotov, S. O.; Gotsulya, A. S.; ZAİKA, Yevhen; BRYTANOVA, Tetyana

doi:10.33483/jfpau.1180794

Cited by 6 publications

(7 citation statements)

References 22 publications

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“…When choosing immunostimulants, preference was given to the triazoline derivatives GKPF-109, synthesised in recent years in Ukraine. Fedotov et al (2023) point out that heterocyclic 1,2,4-triazole compounds are structural fragments of many synthetic drugs that exhibit antifungal (fluconazole, itraconazole), antidepressant (trazodone alprazolam), hepatoprotective, wound healing and antiviral (thiotriazoline) effects, which contain a 3-pyridine fragment as a substituent and lead to the appearance of substances with high pharmacological activity. R. Dubin et al (2022) and A.…”

Section: Indicatorsmentioning

confidence: 99%

Triazoline compounds influence on the meat productivity of turkey carcasses

Dubin,

Paliy,

Sharandak

et al. 2023

Scientific Horizons

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The need to find effective means to improve the quality and production of meat products from poultry farming determines the relevance of the study. The introduction of drugs into the diet can increase the safety of livestock and improve the quality characteristics of poultry meat. The research aims to evaluate the impact of new 1,2,4-triazole derivatives on some blood parameters, as well as meat and slaughter qualities of poultry. The study was conducted between 2022 and 2023 at Odesa State Agrarian University. The trial was conducted to study the effect of new triazoline derivatives GKPF-109 at a dose of 0.5 ml/bird per day on turkey performance and meat quality. The experiment was conducted on Big-6 turkeys aged 1-105 days. The following research methods were used: morphological and biochemical, organoleptic, physicochemical, and statistical. The effects of triazoline derivatives GKPF-109 on organoleptic (appearance, smell, consistency, fat condition, broth quality during meat cooking) and physicochemical studies of turkey meat for microbiological parameters were analysed and investigated following DSTU 3143:2013. The results showed that there was an increase in average daily weight by 13.1%, slaughter yield of gutted carcasses by 12.4%, semi-gutted carcasses by 12.3% and livestock preservation by 4%. An increase in the nutritional value of meat was noted due to an increase in muscle tissue protein by 7.5%, fat by 8.3%, and energy value by 4.8%. The organoleptic, bacteriological, and physicochemical parameters of turkey meat when using triazoline derivatives GKPF-109 in the diet met the requirements of DSTU 3143:2013. It was concluded that the addition of triazoline GKPF-109 derivatives to drinking water enhances haemopoiesis and has antiinflammatory and hepatoprotective effects. The assessment of the quality of broiler turkey meat and broth at the end of the experiment does not allow to assert a decrease in their aroma and taste, which indicates the absence of a negative effect of triazoline derivatives GKPF-109 and methods of their application on the organoleptic characteristics of meat, which should be considered when keeping turkeys

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Section: Indicatorsmentioning

confidence: 99%

Triazoline compounds influence on the meat productivity of turkey carcasses

Dubin,

Paliy,

Sharandak

et al. 2023

Scientific Horizons

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Section: Table 4 Meat Quality and Conformity Of Different Parts Of Tu...mentioning

confidence: 99%

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2023

Scientific Horizons

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Свідоцтво про державну реєстрацію друкованого засобу масової інформації серії КВ № 24997-14937 ПР Науковий журнал включено до категорії А Переліку наукових фахових видань України, у яких можуть публікуватися результати дисертаційних робіт на здобуття наукових ступенів доктора та кандидата ветеринарних, економічних, сільськогосподарських і технічних наук зі спеціальностей: 051 -Економіка; 071 -Облік і оподаткування; 072 -Фінанси, банківська справа та страхування; 073 -Менеджмент; 075 -Маркетинг;

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“…Вибір біологічних мішеней обґрунтований відомостями фахової літератури щодо структурної схожості та можливого механізму дії [9,10].…”

Section: матеріали і методи дослідженняunclassified

Synthesis, molecular docking, and ADME analysis of a series of 4-amino-3,5-dimethyl-1,2,4-triazole derivatives

Kucherenko¹,

Brytanova²,

Gotsulya³

2023

АП

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The heterocyclic system of 1,2,4-triazole enables the successful creation of promising biologically active compounds. By creating a range of derivatives based on 4-amino-3,5-dimethyl-1,2,4-triazole, the spectrum of potential biologically active compounds can be expanded. The aim of the work was the synthesis and in silico justification of the prospects for the search for biologically active compounds among 4-amino-3,5-dimethyl-1,2,4-triazole derivatives. Materials and methods. The work uses modern methods for synthesizing organic compounds, followed by confirmation of their individuality and structure through the analysis of physical-chemical parameters and spectroscopic techniques such as 1H NMR, IR spectroscopy, elemental analysis, and chromatography-mass spectrometry. To assess the similarity of the synthesized compounds to medicinal products, the SwissADME online tool was employed. The probability of impact on a number of enzyme systems (cyclooxygenase-2, lanosterol 14α-demethylase, anaplastic lymphoma kinase) was estimated using molecular docking. Results. A series of newly synthesized derivatives of 4-amino-3,5-dimethyl-1,2,4-triazole was obtained, and the synthesis conditions were optimized and their structures were confirmed. It was determined that there is a high probability of influencing lanosterol 14α-demethylase, highlighting the significance of further research on the antifungal activity of the synthesized compounds. Additionally, the potential influence on the activity of cyclooxygenase-2 and anaplastic lymphoma kinase was discovered. However, the probability of exhibiting the corresponding activities, namely anti-inflammatory and anti-cancer, is low. Physical indicators, parameters of pharmacokinetics, and drug-likeness are important, which determines the prospects of creating biologically active substances based on the synthesized series of compounds. Conclusions. A series of 4-((R-iden)amino)-3,5-dimethyl-1,2,4-triazoles were synthesized, and their general physical-chemical properties were determined. The overall potential for creating innovative biological products based on these compounds was assessed using in silico methods for predicting the activity of substances.

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SYNTHESIS AND PROPERTIES OF A SERIES OF 3-ALKYLTHIO DERIVATIVES 9-METHYLPYRAZOLO[1,5-d][1,2,4]TRIAZOLO[3,4-f][1,2,4]TRIAZINE

Cited by 6 publications

References 22 publications

Triazoline compounds influence on the meat productivity of turkey carcasses

Triazoline compounds influence on the meat productivity of turkey carcasses

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Synthesis, molecular docking, and ADME analysis of a series of 4-amino-3,5-dimethyl-1,2,4-triazole derivatives

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