Synthesis and properties of a novel anisotropic self-inflating hydrogel tissue expander

Swan, Mc C.; Bucknall, David G.; Goodacre, Tim; Czernuszka, Jan T.

doi:10.1016/j.actbio.2010.10.017

Cited by 37 publications

(43 citation statements)

References 34 publications

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“…Similar devices have also been used in surgical reconstruction for burns, scars [4,5] and cleft palate [6]. More recently, anisotropic self-inflating hydrogel expanders have been introduced, where the direction of expansion could be controlled [2,3]. …”

Section: Introductionmentioning

confidence: 99%

“…Self-inflating tissue expanders overcome the limitations associated with the conventional silicone balloon expander, which requires a periodical injection of saline solution into the balloon to slowly stretch the overlaying skin and stimulate growth [1]. This hydrogel expander absorbs body fluid, which leads to a gradual swelling of the device to a definite volume and size, thus stretching the overlaying skin and stimulating growth [2,3]. Similar devices have also been used in surgical reconstruction for burns, scars [4,5] and cleft palate [6].…”

Section: Introductionmentioning

confidence: 99%

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Characteristics and Young's Modulus of Collagen Fibrils from Expanded Skin Using Anisotropic Controlled Rate Self-Inflating Tissue Expander

Manssor

Radzi

Yahya

et al. 2016

Skin Pharmacol Physiol

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Mechanical properties of expanded skin tissue are different from normal skin, which is dependent mainly on the structural and functional integrity of dermal collagen fibrils. In the present study, mechanical properties and surface topography of both expanded and nonexpanded skin collagen fibrils were evaluated. Anisotropic controlled rate self-inflating tissue expanders were placed beneath the skin of sheep's forelimbs. The tissue expanders gradually increased in height and reached equilibrium in 2 weeks. They were left in situ for another 2 weeks before explantation. Expanded and normal skin samples were surgically harvested from the sheep (n = 5). Young's modulus and surface topography of collagen fibrils were measured using an atomic force microscope. A surface topographic scan showed organized hierarchical structural levels: collagen molecules, fibrils and fibers. No significant difference was detected for the D-banding pattern: 63.5 ± 2.6 nm (normal skin) and 63.7 ± 2.7 nm (expanded skin). Fibrils from expanded tissues consisted of loosely packed collagen fibrils and the width of the fibrils was significantly narrower compared to those from normal skin: 153.9 ± 25.3 and 106.7 ± 28.5 nm, respectively. Young's modulus of the collagen fibrils in the expanded and normal skin was not statistically significant: 46.5 ± 19.4 and 35.2 ± 27.0 MPa, respectively. In conclusion, the anisotropic controlled rate self-inflating tissue expander produced a loosely packed collagen network and the fibrils exhibited similar D-banding characteristics as the control group in a sheep model. However, the fibrils from the expanded skin were significantly narrower. The stiffness of the fibrils from the expanded skin was higher but it was not statistically different.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characteristics and Young's Modulus of Collagen Fibrils from Expanded Skin Using Anisotropic Controlled Rate Self-Inflating Tissue Expander

Manssor

Radzi

Yahya

et al. 2016

Skin Pharmacol Physiol

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“…26 Anisotropic hydrogels have been fabricated by applying tensile or compressive forces to shape-anisotropic gel components, e. g., carbon nanotubes or cellulose nanocrystals, within an isotropic hydrogel matrix. 13,15,27,28 Self-assembled fibrils of peptide amphiphiles 26 or lamellar bilayers of polymerizable surfactants 25,27 have been oriented within a hydrogel matrix using shear forces. Alternately, dielectrophoresis has been utilized to align carbon nanotubes in an isotropic hydrogel matrix.…”

Section: Introductionmentioning

confidence: 99%

“…Since many tissues, e.g., striated muscle, 6 cartilage, 7 or cornea 8 , to name just a few examples, have anisotropic hierarchical morphologies, there is a growing interest in developing approaches for the fabrication of anisotropic hydrogels that exhibit direction-dependent pore shape, microstructure, stiffness, and conductivity. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] In tissue engineering, aside from biomimicry, anisotropic pore shape and hydrogel structure, in general, are important for cell guidance 22 and differentiation, 23 as well as mass transport of biofactors and nutrients throughout the scaffold. 19,24,25 In bioseparation, control over the shape anisotropy of hydrogel pores may enhance the selectivity of the filtration of biological species and/or minimize the pressure drop across the matrix.…”

Section: Introductionmentioning

confidence: 99%

Composite Hydrogels with Tunable Anisotropic Morphologies and Mechanical Properties

et al. 2016

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Fabrication of anisotropic hydrogels exhibiting direction-dependent structure and properties have attracted great interest in biomimicking, tissue engineering and bioseparation. Herein, we report a single-step freeze casting-based fabrication of structurally and mechanically anisotropic aerogels and hydrogels composed of hydrazone cross-linked poly(oligoethylene glycol methacrylate) (POEGMA) and cellulose nanocrystals (CNCs). We show that by controlling the composition of the CNC/POEGMA dispersion and the freeze casting temperature, aerogels with fibrillar, columnar, or lamellar morphologies can be produced. Small-angle X-ray scattering experiments show that the anisotropy of the structure originates from the alignment of the mesostructures, rather than the CNC building blocks. The composite hydrogels show high structural and mechanical integrity and a strong variation in Young's moduli in orthogonal directions. The controllable morphology and hydrogel anisotropy, coupled with hydrazone cross-linking and biocompatibility of CNCs and POEGMA, provide a versatile platform for the preparation of anisotropic hydrogels.

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“…Moreover, P(VP-co-HEMA) hydrogel is one of the major synthetic polymers that has been approved by the Food and Drug Administration (FDA) [33] for medical and pharmaceutical applications. Thus, P(VP-co-HEMA) has been extensively studied in biomedical and pharmaceutical applications such as implants for bone substitutes [34], bone tissue regeneration [35], controlled drug delivery [36][37][38], contact lenses [39,40], and tissue expanders for reconstructive plastic surgery [41][42][43][44].…”

Section: Introductionmentioning

confidence: 99%

Effect of monomeric sequence on transport properties of d-glucose and ascorbic acid in poly(VP-co-HEMA) hydrogels with various water contents: molecular dynamics simulation approach

et al. 2012

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We have used full-atomistic molecular dynamics (MD) simulations of both random and blocky sequence hydrogel networks of poly(N-vinyl-2-pyrrolidone-co-2-hydroxyethyl methacrylate) (P(VP-co-HEMA)) with a composition of VP/HEMA = 37:13 to investigate the effect of the monomeric sequence and the water content on the transport properties of ascorbic acid and D-glucose at 310.15 K. The degrees of randomness of the monomer sequence for the random and the blocky copolymers were 1.170 and 0.104, respectively, and the degree of polymerization was fixed at 50. By analyzing the pair correlation functions, it was found that for both monomeric sequences, the guest molecules (i.e., ascorbic acid and D-glucose) have greater accessibility to the VP units than to the HEMA units due to the higher hydrophilicity of VP compared to HEMA units. While the monomeric sequence effect on the P(VPco-HEMA) hydrogel is clearly observed with 20 wt. % water content, the effect is significantly reduced with 40 wt. % water content and disappears completely with 80 wt. % water content. This is because the hydrophilic guest molecules are more likely to be associated with water molecules than with the polymer network at the high water content. By analyzing the diffusion of the guest molecules and the inner-surface area, it is also found that the guest molecules are confined in the system at 20 wt. % water content, resulting in highly anomalous sub-diffusion. Therefore, at low water content, the diffusion of the guest molecules in the hydrogel is directly affected by the monomeric sequence through the interaction of guest molecules with the monomeric units, whereas such monomeric sequence effects are significantly reduced with increasing water content.

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Synthesis and properties of a novel anisotropic self-inflating hydrogel tissue expander

Cited by 37 publications

References 34 publications

Characteristics and Young's Modulus of Collagen Fibrils from Expanded Skin Using Anisotropic Controlled Rate Self-Inflating Tissue Expander

Characteristics and Young's Modulus of Collagen Fibrils from Expanded Skin Using Anisotropic Controlled Rate Self-Inflating Tissue Expander

Composite Hydrogels with Tunable Anisotropic Morphologies and Mechanical Properties

Effect of monomeric sequence on transport properties of d-glucose and ascorbic acid in poly(VP-co-HEMA) hydrogels with various water contents: molecular dynamics simulation approach

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