Synthesis and Properties of AABAAB-Type Macroheterocyclic Compounds with Fragments of 1,2,4- and 1,3,4-Thiadiazole

Butina, Yuliya V.; Данилова, Е. А.; Kudayarova, Tatiana V.

doi:10.6060/mhc160526d

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…[21] In 2016 the Mc of AABAAB-type with expanded coordination cavity was obtained by condensation of bis(5amino-1,3,4-thiadiazole-2-yl)ethane (fragment A) and tertbutyldiiminoisoindoline (fragment B) (Figure 1D). [22] It appears from the above materials, that structural diversity of macroheterocyclic compounds with expanded coordination cavity in comparison with enlarged phthalocyanine analogues [23] is essentially determined by the nature of parent binuclear diamines involved into crossover condensation with phthalogenes. Moreover, binuclear diamines such as bis(5-amino-1,2,4-triazole-3-yl)alkanes and bis(5amino-1,3,4-thiadiazole-2-yl)alkanes have the greatest potential.…”

Section: Introductionmentioning

confidence: 99%

Precursors for the Synthesis of Macroheterocyclic Compounds. Modeling of the Mechanism for Formation of 2-Amino-5-methyl-1,3,4-thiadiazole by Quantum Chemistry Methods

Suvorova¹,

Dunaeva²,

Islyaikin³

2021

MHC

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Section: Introductionmentioning

confidence: 99%

Precursors for the Synthesis of Macroheterocyclic Compounds. Modeling of the Mechanism for Formation of 2-Amino-5-methyl-1,3,4-thiadiazole by Quantum Chemistry Methods

Suvorova¹,

Dunaeva²,

Islyaikin³

2021

MHC

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Synthesis of АВВВ-type macroheterocyclic compounds containing a 3-alkyl-1,3,4-thidiazoline fragment

2017

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The prediction of the spectrum of biological activity and antimicrobial properties of diaminoazoles

et al. 2019

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The work is devoted to predicting and studying biological properties of N-substituted analogs of 3,5-diamino-1,2,4-thiadiazole, which, in their turn, include in the composition of many drugs that exhibit a wide range of pharmacological actions. For searching of new alternative drugs with an antibacterial activity, but lacking resistance of microorganism strains to them, a computer screening of 2N-alkyl-substituted 5-amino-3-imino-1,2,4-thiadiazolines previously synthesized by us was carried out. The prediction of the spectrum of biological activity, as well as the determination of the probable toxicity of these compounds, was performed using the freely available computer programs PASS, Anti-Bac-Pred, and GUSAR. The study of the antibacterial activity in vitro against gram-positive (Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus epidermidis) and gram-negative (Escherichia coli, Pseudomonas aeruginosae) bacterial strains was performed by the disco-diffusion method. Experimental data roughly correspond to the predictions.

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Synthesis and Properties of AABAAB-Type Macroheterocyclic Compounds with Fragments of 1,2,4- and 1,3,4-Thiadiazole

Cited by 3 publications

References 18 publications

Precursors for the Synthesis of Macroheterocyclic Compounds. Modeling of the Mechanism for Formation of 2-Amino-5-methyl-1,3,4-thiadiazole by Quantum Chemistry Methods

Precursors for the Synthesis of Macroheterocyclic Compounds. Modeling of the Mechanism for Formation of 2-Amino-5-methyl-1,3,4-thiadiazole by Quantum Chemistry Methods

Synthesis of АВВВ-type macroheterocyclic compounds containing a 3-alkyl-1,3,4-thidiazoline fragment

The prediction of the spectrum of biological activity and antimicrobial properties of diaminoazoles

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