Synthesis and properties of biodegradable thermo- and pH-sensitive poly[(N-isopropylacrylamide)-co-(methacrylic acid)] hydrogels

Lower critical solution temperature versus volume phase transition temperature in thermoresponsive drug delivery systems

“…Then, the hydrogels are taken out from the solvent and the excess of solvent present on their surface is removed by blotting with filter paper. However, this method, that allows to determine the water retained at different temperatures, is unreliable since the gel is taken out at room temperature and tapped for a random time with a filter paper or laboratory tissue [15,16]. Moreover, in the case of microspheres, this method gives wrong results, since it is not possible to discriminate between the water that is present in the microspheres and the water present between the microspheres.…”

Photo-irradiation paradigm: Mapping a remarkable facile technique used for advanced drug, gene and cell delivery

“…ACCEPTED MANUSCRIPT 24 achieved sustained release was always short and high percentage of release achieved in the first few minutes or hours (burst effect) [77].…”

Injectable chitosan/dextran-polylactide/glycerophosphate hydrogels and their biodegradation

“…To date, several hydrogels prepared with synthetically sourced polymers, such as N-isopropylacrylamide (NiPAAM), poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO) and poly(ethylene glycol)-biodegradable polyester copolymers, have been largely investigated [6][7][8]. Despite injectability, their gel formation usually requires higher polymer concentration, and the resulting hydrogels have slow gel-conversion rate, which leads to limitations of their applications [9].…”