Synthesis and Properties of Diazirinyl Organo-Platinum Compounds for Manipulations of Photoaffinity Labeled Components

Abstract

Synthesis of diazirinyl organo-platinum complexes, which specifically interact with purine base, characterization of photoreactivity and interaction between guanosine 5-monophosphate (GMP) were examined. The results indicated that the diazirinyl organo-platinum complex was useful for manipulations of photoaffinity labeled components.

Microwave-Assisted, Pd(0)-Catalyzed Cross-Coupling of Diazirines with Aryl Halides

“…On the other hand, diazirines are important carbene precursors, and their reaction mechanism upon photolysis and thermolysis has been studied extensively over the past decades . Diazirines are also widely used as photosensitive groups of photoaffinity labeling techniques in biochemical studies . Moreover, reactions of diazirines with transition metal complexes have been documented in the literature .…”