Synthesis and properties of esters and amido esters of 1-(2-thienyl)-2,2,2-trichloroethylphosphorous acid

Amides of Trivalent Phosphorus Acids as Phosphorylating Reagents for Proton-Donating Nucleophiles

“…162,163 Later, the phosphamide method has been widely used to synthesize various functionalized systems, whose molecules contain a trivalent phosphorus atom and other functional groups, e.g., phosphorylated amino [163][164][165][166][167][168] and amido [169][170][171][172][173][174] alcohols, choline, 175,176 partially acetalizedtriols, [177][178][179][180][181] quinine, 182 fagaronin, 183 biotin, [184][185][186] borneol, 164 structural analogues of porphyrins, 187 and halogenated alcohols. [188][189][190] Phosphorylation of functionalized alcohols can be accompanied by additional reactions; this extends the potentialities of classical synthesis and opens up simple routes to interesting heterocycles, for example, Scheme 27.…”

“…Phosphorylation of alkanols and phenols with ATPA is a general process used to prepare esters (or amido esters) of phosphorous acid and other acids of trivalent phosphorus. Initially, this reaction has been used for the synthesis of simple derivatives of the above-mentioned classes of compounds and has been recognized as being not only convenient but also practically feasible 101 for the preparation, in particular, of sterically hindered phenols. , Later, the phosphamide method has been widely used to synthesize various functionalized systems, whose molecules contain a trivalent phosphorus atom and other functional groups, e.g., phosphorylated amino − and amido − alcohols, choline, , partially acetalized triols, − quinine, fagaronin, biotin, − borneol, structural analogues of porphyrins, and halogenated alcohols. − …”