Synthesis and Properties of Polyurethane Elastomers Containing Sucrose as a Cross-Linker

Kizuka, Kazunori; Inoue, Shin‐ichi

doi:10.4236/ojopm.2015.54011

Cited by 11 publications

(10 citation statements)

References 16 publications

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“…They are formed by a urethane linkage (-N-CO-O) in the main chain as a characteristic feature and this linkage is analogous to the peptide bonds in the structure of proteins [9]. In comparison with other conventional materials, polyurethanes possess remarkable properties such as moisture permeability, thermal conductivity, low density, high strength to weight ratio [9][10][11][12]. PUs are used in biomedical science for new applications due to their specific features.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications

et al. 2020

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In this study, new polyurethanes (PUs) were prepared by using inulin and polycaprolactone as polyols. Their structure and morphology were determined by Fourier transform infrared spectroscopy (FTIR), Raman dispersive spectroscopy, Nuclear magnetic resonance spectroscopy ( 1 H NMR and 13 C NMR), and scanning electron microscopy (SEM), whereas their mechanical properties were evaluated by a universal testing machine. Additionally, their water uptake, swelling behavior, and degradation were evaluated to be used as drug delivery carriers. Therefore, an anti-cancer drug was loaded to these PUs with 25% of loading efficiency and its release behavior was studied using different theoretical models to unveil its mechanism. Finally, the ability of the new PUs to be used as a clip marker in breast biopsy was evaluated. The results clearly demonstrate that these PUs are safe and can be used as intelligent drug release matrices for targeted drug delivery and exhibits positive results to be used for clip marker and in general for breast cancer applications.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications

et al. 2020

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“…If the target PURs are intended to be thermosets, the use of crosslinking agent is necessary [5]. The step-growth polyaddition reaction carries a great variability in the compositions including the types and functionality of both the isocyanates and polyols as well as of other additives [5,6,7,8,9]. Furthermore, both isocyanates and polyols can originate from natural resources, such as polyols, e.g., from carbohydrates [6].…”

Section: Introductionmentioning

confidence: 99%

“…M. Barikani et al reacted corn starch with a prepolymer obtained from the reaction of HDI and poly(ε-caprolactone)-diol (PCLD) to prepare hydrophobic PUR-copolymers [8]. Kizuka and Inonue reported the preparation of PURs from aromatic 4,4’-diphenylmethane diisocyanate (MDI), and different polyols and sucrose as a cross linker were reported by putting all reactants in one pot to obtain copolymers [9]. Since our primary purpose was to synthesize flexible, biocompatible and biodegradable PUR-s for potential biological use in general, and pharmaceutical and/or biomedical applications in particular, we encountered some serious limitations.…”

Section: Introductionmentioning

confidence: 99%

Designed Polyurethanes for Potential Biomedical and Pharmaceutical Applications: Novel Synthetic Strategy for Preparing Sucrose Containing Biocompatible and Biodegradable Polyurethane Networks

Nagy

Vadkerti

et al. 2019

Polymers

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In this paper the preparation and detailed characterization of designed polyurethanes (SPURs) are reported for potential biological, biomedical and/or pharmaceutical applications. Importantly, in order to fulfill these goals all reactants and solvents used were selected according to the proposal of EUR-8 Pharmacopoeia. For the synthesis, a novel strategy was introduced and elaborated. A series of SPUR samples was prepared from poly(ε-caprolactone)-diol, 1,6-hexamethylene diisocyanate and sucrose as a chain extender/crosslinking agent to obtain sucrose containing polyurethanes. In addition, the mol ratios of the sucrose were varied within an order of magnitude. The prepolymers and the products of the syntheses were investigated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and infrared spectroscopy (IR), respectively. It was found that the reactivity of the eight free hydroxyl groups of sucrose are different, and after curing the SPUR samples at 60 °C no free isocyanate groups can be observed. Furthermore, swelling experiments performed with various solvents of different polarities revealed that the highest degree of swelling took place in dimethyl-sulfoxide. However, low degrees of swelling were recognized in water and hexane. It is important to note that the gel contents were around 90% in all cases, which demonstrate that the crosslinking was almost complete. In addition, the kinetics of swelling were also evaluated and successfully modeled. The crosslink densities were calculated from the data of the swelling experiments by means of the Flory-Rehner equation. Unexpectedly, it was found that the crosslink density decreased with the increasing sucrose content also in line with the results obtained by relaxation modulus experiments and dynamic mechanical analysis (DMA). The Tg and Tm of SPUR samples, determined from DSC and DMA measurements, were around −57 °C and 27 °C, respectively. According to the mechanical tests the SPUR samples showed high elongation at break values, i.e., high flexibilities. Furthermore, the stress-strain curves were also modeled and discussed.

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“…The presence of sucrose in the polyurethane chain improves the stability and chemical resistance of materials, thus their potential for use in medicine is increased ( Table 3 ). 199 …”

Section: Polymers Obtained From Sugarsmentioning

confidence: 99%

Products of sugar beet processing as raw materials for chemicals and biodegradable polymers

et al. 2018

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Synthesis and Properties of Polyurethane Elastomers Containing Sucrose as a Cross-Linker

Cited by 11 publications

References 16 publications

Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications

Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications

Designed Polyurethanes for Potential Biomedical and Pharmaceutical Applications: Novel Synthetic Strategy for Preparing Sucrose Containing Biocompatible and Biodegradable Polyurethane Networks

Products of sugar beet processing as raw materials for chemicals and biodegradable polymers

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