Synthesis and properties of possible metabolites of dioxidine

Synthesis of fluorinated furo- and pyrrolo[3,4-b]quinoxaline 4,9-dioxides

“…In particular, 2,3-di-(hydroxymethyl)-and 2,3-di(acetoxymethyl)-substituted quinoxaline 1,4-dioxides are known as effective antibacterials. 2 Furo [3,4-b]-and pyrrolo [3,4-b]quinoxaline 4,9-dioxides are also of interest as biologically active compounds, [3][4][5] and a number of synthetic approaches to these heterocyclic systems have been reported in the literature. [2][3][4][5] However, no fluorinated derivatives of furo [3,4-b]-or pyrrolo [3,4-b]quinoxalines have hitherto been described in the literature.…”

“…2 Furo [3,4-b]-and pyrrolo [3,4-b]quinoxaline 4,9-dioxides are also of interest as biologically active compounds, [3][4][5] and a number of synthetic approaches to these heterocyclic systems have been reported in the literature. [2][3][4][5] However, no fluorinated derivatives of furo [3,4-b]-or pyrrolo [3,4-b]quinoxalines have hitherto been described in the literature. Meanwhile, introduction of a fluorine atom into these molecules may change their biological activity dramatically, like it does, for instance, in a series of quinolones.…”