Synthesis and properties of silver nanoparticles in chitosan‐based thermosensitive semi‐interpenetrating hydrogels

Li, Guiying; Wen, Quan; Zhang, Ting; Ju, Yuanyuan

doi:10.1002/app.37609

Cited by 17 publications

(6 citation statements)

References 29 publications

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“…Thus, in this study, we aimed to quantify the amount of Ag + ions released in an in vitro medium and to use for the first time the elements of the pharmacokinetic drug‐delivery paradigm to the nano‐Ag/PVA hydrogel as a model system for the evaluation of the release kinetics and the release mechanism. This was contrary to previous studies, which were mainly based on the development of hydrogel systems as a templates for the synthesis of nanoparticles . In general, it is known that the release of a soluble drug entrapped in a hydrogel should be closely related to the swelling characteristics of the hydrogels.…”

Section: Introductioncontrasting

confidence: 60%

In vitro silver ion release kinetics from nanosilver/poly(vinyl alcohol) hydrogels synthesized by gamma irradiation

Krstić

Spasojević

Radosavljević

et al. 2014

J of Applied Polymer Sci

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A nanosilver (nano-Ag)/poly(vinyl alcohol) (PVA) hydrogel device was synthesized with c irradiation because it is a highly suitable tool for enhanced nano-Ag technologies and biocompatible controlled release formulations. The amount of the Ag 1 ions released in vitro by the nano-Ag/PVA hydrogel device was in the antimicrobial parts per million concentration range. The modeling of the Ag 1 ion release kinetics with the elements of the drug-delivery paradigm revealed the best fit solution (R 2 > 0.99) for the Kopcha and Makoid-Banakar's pharmacokinetic dissolution models. The term A/B, derived from the Kopcha model, indicated that the nano-Ag/PVA hydrogel was mainly an Ag 1 -ion diffusion-controlled device. Makoid-Banakar's parameter and the short time approximated Ag 1 -ion diffusion constant reflected the importance of the size of the Ag nanoparticles. However, it appeared that the cell oxidation potential of the Ag nanoparticles depended on the diffusion characteristics of the fluid penetrating into the Ag/PVA nanosystem.

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Section: Introductioncontrasting

confidence: 60%

In vitro silver ion release kinetics from nanosilver/poly(vinyl alcohol) hydrogels synthesized by gamma irradiation

Krstić

Spasojević

Radosavljević

et al. 2014

J of Applied Polymer Sci

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“…The direct mixing of the antibacterial drug [24] or of nanoparticles [43] , [44] in the hydrogel formation mixture is the most common form of antibacterial hydrogel preparation; however as other steps in the hydrogel formation process are available, they can also be exploited for such purpose. Alternatively, in situ nanoparticle formation has been achieved [45] .…”

Section: Resultsmentioning

confidence: 99%

Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications

González-Sánchez

Perni

Tommasi

et al. 2015

Materials Science and Engineering: C

104

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Infections are frequent and very undesired occurrences after orthopedic procedures; furthermore, the growing concern caused by the rise in antibiotic resistance is progressively dwindling the efficacy of such drugs. Artificial bone graft materials could solve some of the problems associated with the gold standard use of natural bone graft such as limited bone material, pain at the donor site and rejections if donor tissue is used. We have previously described new acrylate base nanocomposite hydrogels as bone graft materials. In the present paper, we describe the integration of silver nanoparticles in the polymeric mineralized biomaterial to provide non-antibiotic antibacterial activity against Staphylococcus epidermidis and Methicillin-resistant Staphylococcus aureus. Two different crosslinking degrees were tested and the silver nanoparticles were integrated into the composite matrix by means of three different methods: entrapment in the polymeric hydrogel before the mineralization; diffusion during the process of calcium phosphate crystallization and adsorption post-mineralization. The latter being generally the most effective method of encapsulation; however, the adsorption of silver nanoparticles inside the pores of the biomaterial led to a decreasing antibacterial activity for adsorption time longer than 2 days.

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“…We have used a well-known precipitation reaction to prepare silver phosphate nanoparticles (SPNPs), as it has been shown in previously published papers [44,45]. Diluted solutions were used to prevent formation of bulky precipitate.…”

Section: Resultsmentioning

confidence: 99%

Complexes of Silver(I) Ions and Silver Phosphate Nanoparticles with Hyaluronic Acid and/or Chitosan as Promising Antimicrobial Agents for Vascular Grafts

Chudobová

Nejdl

Gumulec

et al. 2013

IJMS

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Polymers are currently widely used to replace a variety of natural materials with respect to their favourable physical and chemical properties, and due to their economic advantage. One of the most important branches of application of polymers is the production of different products for medical use. In this case, it is necessary to face a significant disadvantage of polymer products due to possible and very common colonization of the surface by various microorganisms that can pose a potential danger to the patient. One of the possible solutions is to prepare polymer with antibacterial/antimicrobial properties that is resistant to bacterial colonization. The aim of this study was to contribute to the development of antimicrobial polymeric material ideal for covering vascular implants with subsequent use in transplant surgery. Therefore, the complexes of polymeric substances (hyaluronic acid and chitosan) with silver nitrate or silver phosphate nanoparticles were created, and their effects on gram-positive bacterial culture of Staphylococcus aureus were monitored. Stages of formation of complexes of silver nitrate and silver phosphate nanoparticles with polymeric compounds were characterized using electrochemical and spectrophotometric methods. Furthermore, the antimicrobial activity of complexes was determined using the methods of determination of growth curves and zones of inhibition. The results of this study revealed that the complex of chitosan, with silver phosphate nanoparticles, was the most suitable in order to have an antibacterial effect on bacterial culture of Staphylococcus aureus. Formation of this complex was under way at low concentrations of chitosan. The results of electrochemical determination corresponded with the results of spectrophotometric methods and verified good interaction and formation of the complex. The complex has an outstanding antibacterial effect and this effect was of several orders higher compared to other investigated complexes.

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Synthesis and properties of silver nanoparticles in chitosan‐based thermosensitive semi‐interpenetrating hydrogels

Cited by 17 publications

References 29 publications

In vitro silver ion release kinetics from nanosilver/poly(vinyl alcohol) hydrogels synthesized by gamma irradiation

In vitro silver ion release kinetics from nanosilver/poly(vinyl alcohol) hydrogels synthesized by gamma irradiation

Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications

Complexes of Silver(I) Ions and Silver Phosphate Nanoparticles with Hyaluronic Acid and/or Chitosan as Promising Antimicrobial Agents for Vascular Grafts

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