Synthesis and Properties of Tetraaza Macrocycles Containing Two 3‐Pyridylmethyl, 4‐Pyridylmethyl, or Phenylmethyl Pendant Arms and Their Nickel(II) and Copper(II) Complexes: Effects of the Pendant Arms on the Complex Formation Reaction.

Kang, Shin‐Geol; Kim, Seong‐Jin

doi:10.1002/chin.200331188

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“…The mixed-ligand Co(II) complexes with tpmc and another additional ligand were intensively studied [2][3][4][5][6][7] but up to now the X-ray analysis has been performed for only three of them Co 2 (ox)tpmc(ClO 4 ) A great number of termodinamically stable Co(II) complexes with tpmc and other ligands (mono-or dicarboxylates, pseudohalides (NCO, NCS, NCSe) etc.) in macrocyclic enviroment are isolated [5][6][7]9].…”

Section: Introductionmentioning

confidence: 99%

Thermal behavior and biological activity of [Co2(Cl)2 tpmc](BF4)2 complex

Tanasković¹,

Antonijević-Nikolić²,

Dražić³

2021

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A large number of interesting Co (II) complexes with macrocyclicligands have been synthesized and the recognition of its complexes as important bioactive compounds in vitro and in vivo has aroused growing interest in these agents as potential drugs for therapeutic use in various diseases. Numerous available information on their bioinorganic properties and mode of action in several biological systems, combined with the new possibilities imposed by the development of medical chemistry, opens space for the development of a new generation of highly active drugs with minimized side effects which could add significantly to the current clinical research and practice. In this paper we attempt to present some properties of the earlier isolated the first Co(II)tpmc complex for which crystal structure confirmed chair conformation of macrocycle. Complex with formula (Co2(Cl)2tpmc)(BF4)2 (tpmc = N,N`,N``,N```tetrakis(2-pyridylmethyl)-1,4,8,11 - tetraazacyclotetradecane), was studied on thermal behaviour and biological activity. TG-DTA analysis indicates that complex decomposition in a single step in the range of 365 -435 °C. Investigated cytotoxic activity against two human cancer cell lines: HeLa (human cervix adenocarcinoma) and K562 (human myelogenous leukaemia). Complex was also preliminary assayed in vitro toward bacteria, fungi and mould together with the starting material for the synthesis (ligands, simple salts and solvents) as test substances. Investigated complex showed a moderate activity against strains of bacteria and were inactive against the tested fungi and mould. Minimal inhibitory concentration suppressing the visible growth of bacteria was determined. Biological investigations show the complex has significant cytotoxic potential.

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