Synthesis and Properties of Zinc-Modified Hydroxyapatite

Lytkina, Daria; Gutsalova, Anastasiya; Fedorishin, Dmitriy A.; Коротченко, Н. М.; Akhmedzhanov, Rafik Ravilievich; Козик, В. В.; Курзина, И. А.

doi:10.3390/jfb11010010

Cited by 19 publications

(15 citation statements)

References 30 publications

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“…Metal elements such as silver (Ag), gold (Au), copper (Cu), zinc (Zn) [ 16 , 17 ] or combinations thereof and with hydroxyapatite [ 18 , 19 ] have been thoroughly examined as titanium-based material enhancers to improve their antibacterial activity. Strontium (Sr) and silicon (Si) have also been considered as essential trace elements in biological processes [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

A Simple Cerium Coating Strategy for Titanium Oxide Nanotubes’ Bioactivity Enhancement

et al. 2021

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Despite the well-known favorable chemical and mechanical properties of titanium-based materials for orthopedic and dental applications, poor osseointegration of the implants, bacteria adhesion, and excessive inflammatory response from the host remain major problems to be solved. Here, the antioxidant and anti-inflammatory enzyme-like abilities of ceria (CeOx) were coupled to the advantageous features of titanium nanotubes (TiNTs). Cost-effective and fast methods, such as electrochemical anodization and drop casting, were used to build active surfaces with enhanced bioactivity. Surface composition, electrochemical response, and in vitro ability to induce hydroxyapatite (HA) precipitation were evaluated. The amount of cerium in the coating did not significantly affect wettability, yet a growing ability to induce early HA precipitation from simulated body fluid (SBF) was observed as the oxide content at the surface increased. The presence of 4%wt CeOx was also able to stimulate rapid HA maturation in a (poorly) crystalline form, indicating an interesting potential to induce rapid in vivo osseointegration process.

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Section: Introductionmentioning

confidence: 99%

A Simple Cerium Coating Strategy for Titanium Oxide Nanotubes’ Bioactivity Enhancement

et al. 2021

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“…Several authors analyzing nano-hydroxyapatite in critical defects have concluded that porous nano-hydroxyapatite scaffolds can promote angiogenesis in the early stage of bone regeneration, suggesting that the graft has significant potential as a bioactive material for bone regeneration in large-scale defects [15][16][17]. The biochemical mechanism of nanohydroxyapatite VEGF expression-induction and the subsequent blood vessel enhancing effect was not fully described yet.…”

Section: Discussionmentioning

confidence: 99%

Osteopontin and Vascular Endothelial Growth Factor-Immunoreactivity in Critical Bone Defects Matrix Production: A Nano-Hydroxyapatite/Beta-Tricalcium Phosphate and Xenogeneic Hydroxyapatite Comparison

et al. 2021

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The development of new bone substitutes has become an area of great interest in materials science. In fact, hydroxyapatite is the most commonly used biomaterial in defects that require bone reconstruction, and that is certainly why the discovery of new products with its formulation has been increasing continuously. The aim of this study was to analyze the biological behavior of a xenogeneic hydroxyapatite widely disclosed in the literature and a synthetic nano-hydroxyapatite/Beta tricalcium phosphate in critical defects in the calvaria of Wistar rats. For this, the groups were divided as follows: 24 adult male Wistar rats were used, weighing between 300 and 350 g, in three groups with eight animals each. In the CTRL group (control), only the clot was kept, without material insertion; in the Bioss group (bovine hydroxyapatite), Bio Oss®—Gleistlich® was introduced; and in the Blue Bone group (REG), the defect was filled in with synthetic nano-hydroxyapatite associated with betatriphosphate of calcium, Blue Bone®—Regener®. According to the results in Goldner’s Trichromics, we can observe a higher percentage of newly formed bone matrix in the REG group than in the CTRL and Bioss groups; in the VEGF, we had a more adequate cell modulation for blood vessel formation in the Blue Bone group (REG) compared to the Bioss and CTRL groups, while in osteopontin, a higher percentage of bone formation was observed in the Blue Bone group (REG) and Bioss group when compared to the CTRL group. We conclude that bone formation, mitosis-inducing cell modulation and main osteoblast activity were higher in the Blue Bone group (REG) than in the CTRL and Bioss groups.

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“…Elemental analysis was performed before and after the in vivo experiment. To determine the antibacterial activity, the determination of the number of cells by sowing on solid nutrient media (Koch's method) was used according to the standard method of the author's modification [7]. To determine biocompatibility in vivo, the technique provided by GOST ISO 10993-1-2011 in the author's modification was used [7].…”

Section: Materials and Research Methodsmentioning

confidence: 99%

Research of the Influence of Zinc Ions on Synthesis and Properties of Hydroxyapatite

Fedorishin

Gutsalova

Lytkina

et al. 2020

The 1st International Electronic Conference on Applied Sciences

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Hydroxyapatites modified with metal ions are the main inorganic components of bone tissue that are approved for use as components for biocomposites and coatings for surgical implants. This study examined prototypes of functional materials for bone implants based on hydroxyapatite modified with zinc ions. Antibacterial activity and biocompatibility have been established. The studied materials have antimicrobial activity, the samples did not cause significant changes both in the internal organs and in the general condition of laboratory animals during the entire experiment.

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Synthesis and Properties of Zinc-Modified Hydroxyapatite

Cited by 19 publications

References 30 publications

A Simple Cerium Coating Strategy for Titanium Oxide Nanotubes’ Bioactivity Enhancement

A Simple Cerium Coating Strategy for Titanium Oxide Nanotubes’ Bioactivity Enhancement

Osteopontin and Vascular Endothelial Growth Factor-Immunoreactivity in Critical Bone Defects Matrix Production: A Nano-Hydroxyapatite/Beta-Tricalcium Phosphate and Xenogeneic Hydroxyapatite Comparison

Research of the Influence of Zinc Ions on Synthesis and Properties of Hydroxyapatite

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