Synthesis and quantitative structure-activity relationship of a new series of chiral 4-alkoxycarbonyl-2-(alkylamino)-1,3,2-oxa or thiazaphospholidine-2-ones

Synthesis of 1,3-bis(4,5-dihydrothiazole) benzene

“…In the literature it has been reported that reaction of L-cysteine ethyl ester hydrochloride with carbon disulfide in the presence of triethyl amine in CH 2 Cl 2 at room temperature yielded a five membered ring [14]. Similarly, esterification of L-(R)-cysteine followed by reaction with phosphoryl chloride and two moles of triethylamine, yielded cyclic phosphoramidothiolic chloride [15], a five membered ring.…”