Synthesis and Quantitative Structure-Activity Relationships of Antibacterial 1-(Substituted Benzhydryl)-4-(5-nitro-2-furfurylideneamino)piperazines

Yung, D. K.; Gilroy, M.L.; Mahony, D. E.

doi:10.1002/jps.2600670707

Cited by 11 publications

(3 citation statements)

References 13 publications

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“…A number of substituted piperazines posses significant pharmacological action such as antihistamic [1][2] antimicrobial, 3 acetylcholinesterae inhibitors 4 , antimalarial 5 , dopamine transporter [6][7] , D 2 /D 4 antagonist 8 , MC 4 Receptor 9 , and HIV-protease inhibitor [10][11] . Under this category, benzhydrilpiperazine (diphenylmethylpiperazine) belongs to the diarylpiperazine family; possesses wide range of pharmacological properties such as anti-lipid-peroxidation activity 12 , antiallergic and antioxidant activity 13 antihistamic activity 14 , myocardiuminhibiting agent 15 and antimicrobial activity [16][17] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Amino Acids Conjugated Diphenylmethylpiperazine Derivatives

Shivakumara

Prakasha

Gowda

2009

Journal of Chemistry

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A series of amino acid conjugated diphenylmethylpiperazine derivatives were synthesized by coupling diphenylmethylpiperazine with different Boc-amino acids using EDCI/HOBt as coupling agent and NMM as base. The synthesized compounds were characterized by1H-NMR and elemental analysis. The Boc-deblocked derivatives were tested for their antimicrobial activity. We are here reporting that Phe and Trp conjugated diphenylmethylpiperazine showed equally good antibacterial activities as that of conventional antimicrobial drugs.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Amino Acids Conjugated Diphenylmethylpiperazine Derivatives

Shivakumara

Prakasha

Gowda

2009

Journal of Chemistry

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“…The crude product was chromatographed on silica (petroleum ether/EtOAc) to give a white solid, mp 62–65 °C [69–70 °C], 83% (52.9 mg). 1 H NMR (400 MHz, CDCl 3 ) δ 7.28–7.21 (m, 4H), 7.13 (d, J = 8.0 Hz, 4H), 5.78 (s, 1H), 2.32 (s, 6H).…”

Section: Methodsmentioning

confidence: 99%

Visible Light Induced Reduction and Pinacol Coupling of Aldehydes and Ketones Catalyzed by Core/Shell Quantum Dots

Yang

Wang

et al. 2021

J. Org. Chem.

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We present an efficient and versatile visible light-driven methodology to transform aryl aldehydes and ketones chemoselectively either to alcohols or to pinacol products with CdSe/CdS core/shell quantum dots as photocatalysts. Thiophenols were used as proton and hydrogen atom donors and as hole traps for the excited quantum dots (QDs) in these reactions. The two products can be switched from one to the other simply by changing the amount of thiophenol in the reaction system. The core/shell QD catalysts are highly efficient with a turn over number (TON) larger than 4 × 104 and 4 × 105 for the reduction to alcohol and pinacol formation, respectively, and are very stable so that they can be recycled for at least 10 times in the reactions without significant loss of catalytic activity. The additional advantages of this method include good functional group tolerance, mild reaction conditions, the allowance of selectively reducing aldehydes in the presence of ketones, and easiness for large scale reactions. Reaction mechanisms were studied by quenching experiments and a radical capture experiment, and the reasons for the switchover of the reaction pathways upon the change of reaction conditions are provided.

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“…Benzhydrol and its analogues are important intermediates in pharmaceutical industry [1]. Routinely, benzhydrols were prepared by reduction from corresponding benzophenones.…”

Section: Introductionmentioning

confidence: 99%

Efficient and mild room temperature reduction of benzophenones under ultrasound irradiation

Peng

Zhong

Song

2005

Ultrasonics Sonochemistry

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Synthesis and Quantitative Structure-Activity Relationships of Antibacterial 1-(Substituted Benzhydryl)-4-(5-nitro-2-furfurylideneamino)piperazines

Cited by 11 publications

References 13 publications

Synthesis and Antimicrobial Activity of Amino Acids Conjugated Diphenylmethylpiperazine Derivatives

Synthesis and Antimicrobial Activity of Amino Acids Conjugated Diphenylmethylpiperazine Derivatives

Visible Light Induced Reduction and Pinacol Coupling of Aldehydes and Ketones Catalyzed by Core/Shell Quantum Dots

Efficient and mild room temperature reduction of benzophenones under ultrasound irradiation

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