Synthesis and radiolabeling of vitamin C-stabilized selenium nanoparticles as a promising approach in diagnosis of solid tumors

Korany, Mohamed; Mahmoud, Basant; Ayoub, S. M.; Sakr, Tamer M.; Ahmed, Sayed A.

doi:10.1007/s10967-020-07195-5

Cited by 14 publications

(10 citation statements)

References 43 publications

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“…Inorganic NPs can be chemically synthesized using several different techniques such as co-precipitation, hydrothermal, combustion, sol-gel, chemical reduction, chemical vapor and microwave-assisted methods [ 67 , 68 , 69 , 70 , 71 ]. In this review, we present inorganic NPs that are synthesized using reducing and stabilizing agents where the reducing agent is responsible for the reduction of the metal from high oxidation states (+3, +2 or +1) to its metallic form (zero oxidation state), while the stabilizing agent is responsible for surface stabilization of metal nano materials [ 22 , 42 , 44 , 45 , 47 , 49 , 50 , 52 ]. Various NPs including AuNPs, selenium nanoparticles (SeNP), iron nanoparticles (FeNP), copper nanoparticles (CuNP) and silver nanoparticles (AgNP) were evaluated for their effective delivery of different radionuclides such as tecnetium-99m (Tc-99m), iodine-131 (I-131) and gold-198 (Au-198) to tumor sites for tumor theranostics [ 42 , 44 , 45 , 47 , 48 , 49 , 50 , 51 , 52 , 72 ].…”

Section: Design and Development Of Nanoparticlesmentioning

confidence: 99%

IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery

et al. 2022

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The rapidly growing interest in the application of nanoscience in the future design of radiopharmaceuticals and the development of nanosized radiopharmaceuticals in the late 2000′s, resulted in the creation of a Coordinated Research Project (CRP) by the International Atomic Energy Agency (IAEA) in 2014. This CRP entitled ‘Nanosized delivery systems for radiopharmaceuticals’ involved a team of expert scientist from various member states. This team of scientists worked on a number of cutting-edge areas of nanoscience with a focus on developing well-defined, highly effective and site-specific delivery systems of radiopharmaceuticals. Specifically, focus areas of various teams of scientists comprised of the development of nanoparticles (NPs) based on metals, polymers, and gels, and their conjugation/encapsulation or decoration with various tumor avid ligands such as peptides, folates, and small molecule phytochemicals. The research and development efforts also comprised of developing optimum radiolabeling methods of various nano vectors using diagnostic and therapeutic radionuclides including Tc-99m, Ga-68, Lu-177 and Au-198. Concerted efforts of teams of scientists within this CRP has resulted in the development of various protocols and guidelines on delivery systems of nanoradiopharmaceuticals, training of numerous graduate students/post-doctoral fellows and publications in peer reviewed journals while establishing numerous productive scientific networks in various participating member states. Some of the innovative nanoconstructs were chosen for further preclinical applications—all aimed at ultimate clinical translation for treating human cancer patients. This review article summarizes outcomes of this major international scientific endeavor.

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Section: Design and Development Of Nanoparticlesmentioning

confidence: 99%

IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery

et al. 2022

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“…Production of Se-NPs coated with ascorbic acid was achieved through the bioreduction of selenite (Na 2 SeO 3 ) [ 106 ]. Selenite was mixed with ascorbic acid and the mixture turned orange red after 30 min, confirming the fabrication of Se-NPs.…”

Section: Green Synthesis-based Systemsmentioning

confidence: 99%

Lichens—A Potential Source for Nanoparticles Fabrication: A Review on Nanoparticles Biosynthesis and Their Prospective Applications

Hamida

Ali

Abdelmeguid

et al. 2021

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Green synthesis of nanoparticles (NPs) is a safe, eco-friendly, and relatively inexpensive alternative to conventional routes of NPs production. These methods require natural resources such as cyanobacteria, algae, plants, fungi, lichens, and naturally extracted biomolecules such as pigments, vitamins, polysaccharides, proteins, and enzymes to reduce bulk materials (the target metal salts) into a nanoscale product. Synthesis of nanomaterials (NMs) using lichen extracts is a promising eco-friendly, simple, low-cost biological synthesis process. Lichens are groups of organisms including multiple types of fungi and algae that live in symbiosis. Until now, the fabrication of NPs using lichens has remained largely unexplored, although the role of lichens as natural factories for synthesizing NPs has been reported. Lichens have a potential reducible activity to fabricate different types of NMs, including metal and metal oxide NPs and bimetallic alloys and nanocomposites. These NPs exhibit promising catalytic and antidiabetic, antioxidant, and antimicrobial activities. To the best of our knowledge, this review provides, for the first time, an overview of the main published studies concerning the use of lichen for nanofabrication and the applications of these NMs in different sectors. Moreover, the possible mechanisms of biosynthesis are discussed, together with the various optimization factors influencing the biological synthesis and toxicity of NPs.

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“…Therefore, incorporation strategy is also called intrinsic radiolabeling method in some previous reports ( Goel et al, 2014 ; Chakravarty et al, 2018 ; Fach et al, 2021 ), which could essentially guarantee an accurate reflection of NMs behavior by detecting the radioactive signals. In addition to radiochemical synthesis starting from the cold-hot precursors, radionuclide can be incorporated into the NMs through surface elemental exchange, or radionuclide deposition in cage-like/mesoporous NMs ( Goel et al, 2014 ; Tang et al, 2019 ; Korany et al, 2020 ). NMs can also be radioactively activated via thermal and epithermal neutron bombardment before the tracing study ( Antsiferova et al, 2015 ).…”

Section: Radiolabeling Strategiesmentioning

confidence: 99%

“…In the existing literature, the radiochemical stability of the NMs-radiometals complex has always been investigated ex vivo as follows: after the direct (chelator-free) or indirect (typically chelator-based) chemical bond formation between the radiometals and the NMs surface, the complex is incubated in simulated body fluids (i.e., serum or PBS at 37°C) for several hours or overnight, and then the detached radiometals are collected and quantified by means of centrifugation, chromatography, or liquid chromatography ( Korany et al, 2020 ; Wang L. Z. et al, 2020 ; Papadopoulou et al, 2021 ). However, one of our work just demonstrated that some features of the particokinetics may lead to a previously underappreciated loss in the in vivo stability of radiolabeling ( Zhang et al, 2019 ).…”

Section: In Vivo Stability Of Radiolabelingmentioning

confidence: 99%

Radiolabeling of Nanomaterials: Advantages and Challenges

et al. 2021

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Quantifying the distribution of nanomaterials in complex samples is of great significance to the toxicological research of nanomaterials as well as their clinical applications. Radiotracer technology is a powerful tool for biological and environmental tracing of nanomaterials because it has the advantages of high sensitivity and high reliability, and can be matched with some spatially resolved technologies for non-invasive, real-time detection. However, the radiolabeling operation of nanomaterials is relatively complicated, and fundamental studies on how to optimize the experimental procedures for the best radiolabeling of nanomaterials are still needed. This minireview looks back into the methods of radiolabeling of nanomaterials in previous work, and highlights the superiority of the “last-step” labeling strategy. At the same time, the problems existing in the stability test of radiolabeling and the suggestions for further improvement are also addressed.

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Synthesis and radiolabeling of vitamin C-stabilized selenium nanoparticles as a promising approach in diagnosis of solid tumors

Cited by 14 publications

References 43 publications

IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery

IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery

Lichens—A Potential Source for Nanoparticles Fabrication: A Review on Nanoparticles Biosynthesis and Their Prospective Applications

Radiolabeling of Nanomaterials: Advantages and Challenges

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