Synthesis and reactions of 2-chloro-2-(hydroximino)-1-(4-methyl-2-phenylthiazol-5-yl)ethanone

Abstract

3‐Nitrosoimidazo[1,2‐a]pyridine, 3‐nitrosoimidazo[1,2‐a]pyrimidine, 3‐nitrosoquinoxaline, 2‐nitroso‐4H‐benzo[b]thiazine, 2‐nitroso‐4H‐benzo[b]oxazine, isoxazoles, isoxazolo[3,4‐d]pyridazines and pyrrolo[3,4‐d]isoxazole‐4,6‐dione were synthesized from 2‐chloro‐2‐(hydroximino)‐1‐(4‐methyl‐2‐phenylthiazol‐5‐yl)ethanone and different reagents. Structures of the newly synthesized compounds were confirmed by elemental analysis and spectral data.

Fused Heterocycles: Synthesis and Antitubercular Activity of Novel 6‐Substituted‐2‐(4‐methyl‐2‐substituted phenylthiazol‐5‐yl)H‐imidazo[1,2‐a]pyridine

“…The starting material 1‐(4‐methyl‐2‐phenylthiazol‐5‐yl)ethanone 1a , 1b , 1c , 1d was synthesized by cyclocondensation of aryl thioamide with 3‐bromopentane‐2,4‐dione. 1‐(4‐Methyl‐2‐phenylthiazol‐5‐yl)ethanone 1a , 1b , 1c , 1d on bromination with bromine in dichloromethane (DCM) gave 2‐bromo‐1‐(4‐methyl‐2‐substituted phenylthiazol‐5‐yl)ethanone 2a , 2b , 2c , 2d , which on cyclocondensation with substituted 2‐aminopyridine 3a , 3b , 3c furnished target compounds 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j , 4k , 4l . The physical properties of synthesized compounds are given in Table .…”