Synthesis and Reactions of New Thienopyridines, Pyridothieniopyrimidines and Pyridothienotriazines

Abstract

4-Aryl-3-cyano-6-(2'-thienyl)-pyridine-2(1H)-thiones (1a-c) were reacted with phenacyl bromide, chloro-Narylacetamides or 2-chloroacetylaminopyridine to furnish 2-functionalized 3-amino-4-aryl-6-(2'-thienyl)-thieno[2,3-b]pyridines 4a-c and 5a-c or 5d respectively. The compounds 5a-d underwent different sequence of reactions to produce a variety of thienylpyridothienopyrimidines and, thienylpyridothienotriazines. Some of the prepared compounds were tested in vitro for their antimicrobial activities.

Chelating Behaviour of Dihydrothieno[3,4, d] Pyridazine Derivatives with Some Lanthanide and Actinide Metals

“…Recently pyridazine and thienopyridazine compounds have been reported to possess varied biological activities such as antimicrobial 1 , antihypertensive 2,3 , anti-inflammatory 4 , antifungal activities 5 , antimalarials [6][7][8][9][10][11][12][13][14] .Pyridazinone nucleus has been extensively studied in the search for new and selective medicinal agents as drugs acting on the cardiovascular system 15 . Furthermore, a number of thienopyridazines have been claimed to possess interesting biological and pharmacological activities such as, anticancer 16 , useful as oxidase inhibitor [17][18] . Complexation of thienopyridazine with transition and rare earth metals have been studied [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] .…”