Synthesis and reactions of some new benzopyranone derivatives with potential biological activities

El‐Desoky, El‐Sayed I.; Al‐Shihry, Shar S.

doi:10.1002/jhet.5570450648

Cited by 15 publications

(2 citation statements)

References 34 publications

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“…This would be accompanied by cyclodehydration, leading eventually to the pyridopyrrolopyrimidine12a with N-3-aminolactam structure. The results of several investigations reported recently support this hypothesis [39][40][41][42]. It is worth mentioning that Naminolactam structure 12a was confirmed by an alternative synthetic route involving initial acetylation of the ester 2a with acetic anhydride and subsequent cyclization of the formed N-acetyl derivative 6b with hydrazine hydrate.…”

Section: Results and Discussion:-mentioning

confidence: 53%

New Condensed Bioactive Pyrimidines. Synthetic Strategies, Structural Characterization and Biorational Studies.

El-Torgoman¹,

Zaki²,

Sherif³

et al. 2016

IJAR

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importance [1-4]. Many studies have been evaluated about the mode of action of different chemicals against pests as well as bacteria and other microorganisms. Mosquitoes are generally controlled by conventional chemical insecticides, but insect growth inhibitors and insect growth regulators, in general, have been employed in the laboratory against different species of mosquitoes. It has been reported [5] that the three chitin synthesis inhibitors (diflubenzuron, nikkomycin Z and polyoxin D) produced toxicities against Anopheles quadrimaculatus. It is well documented[6] that increased resistance of malaria parasites to drug treatment against mosquito vectors to insecticides requires the development of novel chemotherapeutic agents. In recent studies [7, 8], it has been described that benzoylphenyl urea derivatives such as Alsystin (Triflumuron) and Andalin (Flucycloxuron) were found to disturb the growth and development in Culexpipiens. On the other hand, Cassera et al. [6] mentioned that Plasmodium purine and pyrimidine metabolic pathways are distinct from those of their hosts. Thus, targeting purine and pyrimidine metabolic pathways provides a promising route for novel drug development [9]. Furthermore, the pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine structure was characterized as a new class of potent and selective human A 3 adenosine receptor antagonists [9]. High-affinity radioligand antagonist for this receptor subtype, designated as [ 3 H]MRE2008F20 [10]. Accordingly, an aquatic insect, the larva of the mosquito (CulexpipiensL.) was chosen for the purpose and proved to be an excellent for test. Based on these observations and as part of our ongoing studies in the development of new chemotherapeutic agents [11, 12,13], we embarked upon the synthesis of a series of novel condensed tricyclic derivatives containing a pyrido[3',2':4,5]pyrrolo[3,2-d]pyrimidine core with the objective to assess new biorational agents on mosquitoes Culexpipiensand to improve their efficacy. Materials and methods:-Chemistrymaterials:-Melting points are uncorrected. IR analyses were performed (KBr) with a PyeUnicam SP-1000 spectrophotometer. IR spectra of compounds are expressed by wavenumber (cm-1). NMR spectra were obtained on a Varian Gemini 300 MHz spectrometer in DMSO-d 6 as solvent. Chemical shifts of the 1 H NMR spectra are reported in δ (ppm) from tetramethylsilane with the solvent as the), anhydrous potassium carbonate (0.01 mol) and ethyl glycinate (0.0075 mol) were added. The reaction mixture was heated at reflux for 2.5 h and then allowed to stand at room temperature overnight under stirring. The reaction mixture was then diluted with cold water, whereby the resulting precipitate was collected by filtration, repeatedly washed with cold water and dried. Recrystallization from DMF-H 2 O gave pale yellow crystals of the title compound 2 (0

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Section: Results and Discussion:-mentioning

confidence: 53%

New Condensed Bioactive Pyrimidines. Synthetic Strategies, Structural Characterization and Biorational Studies.

El-Torgoman¹,

Zaki²,

Sherif³

et al. 2016

IJAR

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“…Benzopyranones and furobenzopyranones are compounds of considerable significance owing to their wide spread occurrence in plants and their potential as important pharmaceuticals in the treatment of renal colic, anginal syndromes, whooping cough, peptic ulcer, in photochemotherapy treatment of a variety of skin diseases such as psoriasis, vitiligo, mycosis fungoides, as antiviral, antitumor, antiproliferation and CNS agents [5].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of linear hetarenochromones based on 7-hydroxy-6-formyl(acetyl)chromones

2021

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Fused chromones are attracting increasing attention as novel therapeutic agents due to their wide distribution in nature, effective bioactivities and low toxicity. 6-Carbonyl-7-hydroxychromones proved to be versatile synthons for the synthesis of linear hetarenochromones by annulation of heterocycle to the chromone core. The present review is focused on the syntheses of furo[3,2-g]chromones, pyrano[3,2-g]chromones and some of their N-containing analogues, namely chromeno[6,7-d]isoxazoles, pyrano[3’,2’:6,7]chromeno[4,3-b]pyridine-5,11-diones and pyrano[3’,2’:6,7]chromeno[4,3-c]pyridine-5,11-diones based on the 7-hydroxy-6-formylchromones or 7-hydroxy-6-acetylchromones and shows the current state of research to date. The methods for the synthesis of the starting 7-hydroxy-6-formylchromones and 7-hydroxy-6-acetylchromones have been also mentioned. The biological activity of naturally occurring and modified synthetic linear hetarenochromones has been also represented.

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ChemInform Abstract: Synthesis and Reactions of Some New Benzopyranone Derivatives with Potential Biological Activities.

El‐Desoky

Al‐Shihry

2009

ChemInform

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Synthesis and reactions of some new benzopyranone derivatives with potential biological activities

Cited by 15 publications

References 34 publications

New Condensed Bioactive Pyrimidines. Synthetic Strategies, Structural Characterization and Biorational Studies.

New Condensed Bioactive Pyrimidines. Synthetic Strategies, Structural Characterization and Biorational Studies.

Synthesis of linear hetarenochromones based on 7-hydroxy-6-formyl(acetyl)chromones

ChemInform Abstract: Synthesis and Reactions of Some New Benzopyranone Derivatives with Potential Biological Activities.

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