Synthesis and Reactions of Some Novel Nicotinonitrile, Thiazolotriazole, and Imidazolotriazole Derivatives for Antioxidant Evaluation

A Review: Synthesis and Medicinal Importance of Nicotinonitriles and Their Analogous

“…Some of the prepared products were selected and subjected to screening for their antioxidant activity. In general, compound 17 showed the greatest effect against the artificial radical DPPH as compared with the other compounds (Scheme ) .…”

“…Furthermore, Sayed et al . synthesized the pyridone derivative 6 via one‐pot three‐component reactions of the appropriate chalcones 5 with malononitrile and ammonium acetate in EtOH (Scheme ) . Next, condensation of compound 6 with ethyl chloroacetate in pyridine gave the ester 7 , which condensed with thiosemicarbazide and/or hydrazine hydrate afforded the mercaptotriazole and the acetic acid 8 and 9 , respectively.…”

“…Next, condensation of compound 6 with ethyl chloroacetate in pyridine gave the ester 7 , which condensed with thiosemicarbazide and/or hydrazine hydrate afforded the mercaptotriazole and the acetic acid 8 and 9 , respectively. The latter compound reacted with ethyl acetoacetate, ethyl cyanoacetate, and maleic anhydride to give compounds 10 , 11 , and 12 , respectively (Scheme ) .…”

Novel Nicotinonitriles and Thieno[2,3‐b]pyridines as Potent Biofilm and COX‐2 Inhibitors: Synthesis, In Vitro and In Silico Studies

“…Also, these inhibitors overcome apoptosis and drug resistance as well as suppress of immune responses. [19,20] Furthermore, nicotinonitrile derivatives exhibit excellent biological activities as antioxidant, [21,22] anti-inflammatory, [23,24] anti-Alzheimer, [25] anticonvulsant, [26] antitubulin [27] and antiproliferative [28] agents as well as protein kinases inhibitors. [29] Moreover, thieno [2,3-b]pyridine derivatives showed tremendous medicinal and biological activities as antimicrobial, [30,31] antiviral, [32,33] anti-inflammatory, [34][35][36] antidiabetic [37,38] and antihypertensive agents.…”

Design and synthesis of new series of 3‐cyanopyridine and pyrazolopyridine derivatives

“…Pyridine is one of the most popular moieties incorporated into the structure of wide range of biologically active compounds. Among these, cyanopyridines (nicotinonitriles) have various biological activities, as antimicrobial [8][9][10], anticancer [10][11], antihypertensive [12], analgesic, antipyretic, anti-inflammatory [13][14][15], antioxidant [16][17][18][19], anti-Alzheimer [20], and anticonvulsant [21]. On the other hand, some nicotinonitrile derivatives are used as electrical materials [22] and optical materials [23].…”