Synthesis and reactions of some 6‐(2‐hydroxy‐1‐naphthyl)‐1,2,4‐triazines

Eid, Mohga M.; Kadry, Azza M.; Hassan, R. A.

doi:10.1002/jhet.5570250414

Cited by 6 publications

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, only a few studies have investigated the synthesis of benzofurotriazine derivatives. In 1988, Eid et al reported the synthesis of naphthofuro[2,3- e ][1,2,4]triazine in a 33% overall yield via the annulation of the triazine core to naphthofuran-1,2-dione [ 51 ]. The reaction was carried out in four steps.…”

Section: Introductionmentioning

confidence: 99%

MnO2-Mediated Oxidative Cyclization of “Formal” Schiff’s Bases: Easy Access to Diverse Naphthofuro-Annulated Triazines

et al. 2022

View full text Add to dashboard Cite

A different type of MnO2-induced oxidative cyclization of dihydrotriazines has been developed. These dihydrotriazines are considered as a “formal” Schiff’s base. This method provided easy access to naphthofuro-fused triazine via the C-C/C-O oxidative coupling reaction. The reaction sequence comprised the nucleophilic addition of 2-naphthol or phenol to 1,2,4-triazine, followed by oxidative cyclization. The scope and limitations of this novel coupling reaction have been investigated. Further application of the synthesized compound has been demonstrated by synthesizing carbazole-substituted benzofuro-fused triazines. The scalability of the reaction was demonstrated at a 40 mmol load. The mechanistic study strongly suggests that this reaction proceeds through the formation of an O-coordinated manganese complex.

show abstract

Section: Introductionmentioning

confidence: 99%