Synthesis and Sar Strategy of Thiazolidinedione: A Novel Approach for Cancer Treatment

Abstract

In current review, authors aim to inspire the researcher through structure activity relationship strategy for the finding of safe and effective anticancer molecules. Nowadays cancer is measured as one of the major health problems in human beings in the world from decades. A classes of heterocyclic compounds have been recognized through molecular biology, empirical screening and rational drug development for the evaluation of anticancer molecules however regrettably, till now we could not find a medicine to be entirely active and nontoxic for the treatment of cancer patients. In pointed view, it might be measured that Thiazolidinedione (TZD) heterocyclic compounds are prodigious standing in the synthetic and pharmacological approach of medicinal chemistry. Thiazolidinedione (TZD) nucleus upon the substitution of various functional groups is provides a wide spectrum of biological activity by the use of different mechanism on different target sites. Recently, some of the substituted thiazolidinedione molecules are designed for the treatment of human cancers cell line through different molecular mechanism such as EGFR & Mushroom Tyrosine kinase inhibitor, COX enzyme inhibitors, Histone deacetylase inhibitors, Alpha glucosidase inhibitor, DNA intercalation and Protein tyrosine phosphatase 1B (PTP1B) inhibitor, basically in which PPAR gamma express are in high levels. Peroxisome proliferator-activated receptor (PPAR) gamma ligands effect on apoptosis, cell proliferation and cell differentiation on different types of cell. The most commonly cascades in human cancers cell are Raf/MEK/ERK, Wnt and PI3/Akt. This article highlights and embraces a concise overview of recent approaches for the synthesis of new thiazolidinedione molecules with its structure activity relationship strategy and effects on various signaling pathways, which is responsible for the expresses of cancer cell line activity.

Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targets

“…N -based heterocyclic compounds have attracted much interest and attention from medicinal chemists and biologists. Their broad range of biological activities and wide applications in the design of drugs with exceptional selectivity for DNA via hydrogen bonding interaction has contributed to their high propensity for conferring anti-cancer properties on various synthetic and natural compounds in which they occur [ 44 ].…”

Effect of a novel thiazole derivative and its complex with a polymeric carrier on stability of DNA in human breast cancer cells

“…Cancer is a serious global health problem that is characterized by abnormal and uncontrolled cell division [1,2]. Breast cancer is the second most frequent cause of death among women [1,3].…”

“…Cancer is a serious global health problem that is characterized by abnormal and uncontrolled cell division [1,2]. Breast cancer is the second most frequent cause of death among women [1,3]. Chemotherapy (hormonal or nonhormonal), radiotherapy and surgery are used for breast cancer treatment.…”

“…Chemotherapy (hormonal or nonhormonal), radiotherapy and surgery are used for breast cancer treatment. However, the resistance of breast cancer cells to chemotherapy is rapidly developing [1,4]. Thus, it is crucial to develop novel treatment strategies.…”

“…The thiazole derivatives are characterized by a wide range of biological activities (anticancer, antibacterial, antifungal, antiviral, anti-inflammatory, neuroprotective) [1,[5][6][7][8][9][10][11]. Anticancer activity was reported for tiazofurin, dasatinib, and a furan-thiazole hybrid [11,12].…”