“…They have found widespread application in medicinal chemistry 2 and materials science. 3 They are also found in many pharmaceutical compounds ( Figure 1), such as saripidem 4 (anxiolytic, I), olprinone 5 (to treat acute heart failure, II), zolimidine 6 (antiulcer, III), and zolpidem 7 (hypnotic, IV), which exhibit antifungal, 8 antiinflammatory, 9 antitumor, 10 antiviral, 11 antibacterial, 12 antiprotozoal, 13 antipyretic, 14 analgesic, 15 antiapoptotic, 16 hypnoselective, and anxioselective activities. 17 Consequently, there is considerable interest from the pharmaceutical industry, synthetic chemists and this has stimulated the development of numerous methods for their preparation.…”