Synthesis and Screening of Cyclic Benzylhydrazine Congeners as Antidepressants

Taha, Aly M.; Omar, Nagwa M.; Bayomi, Said M.; Ammar, Elsayed M.; Afifi, Abdel-Halim M.

doi:10.1002/jps.2600630316

Cited by 9 publications

(7 citation statements)

References 12 publications

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“…Pursuing their research on cyclic benzylhydrazine congeners as antidepressants, Taha et al reported on the synthesis and pharmacological evaluation of new 3-arylpyrazolidines incorporating the basic benzylhydrazine skeleton -C 6 H 4 -C-N-N-in a cyclic form and comparing them with their corresponding unsaturated analogues (pyrazolines) [20].…”

Section: Pyrazolidine Derivativesmentioning

confidence: 99%

“…The 3-aryl pyrazolines may be regarded as the cyclic congeners of benzylhydrazine. The first work reported on the synthesis and pharmacological evaluation of a series of new 3-aryl-2-pyrazolinium perchlorates incorporating the basic benzylhydrazine skeleton -C 6 H 4 -C-N-N-in a cyclic form [20].…”

Section: Pyrazoline Derivatives As Antidepressant and Anticonvulsant mentioning

confidence: 99%

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The State of the Art of Pyrazole Derivatives as Monoamine Oxidase Inhibitors and Antidepressant/Anticonvulsant Agents

Secci

Bolasco²,

Chimenti³

et al. 2011

CMC

103

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Monoamine oxidase plays a significant role in the control of intracellular concentration of monoaminergic neurotransmitters or neuromodulators and dietary amines. The rapid degradation of these molecules ensures the proper functioning of synaptic neurotransmission and is critically important for the regulation of emotional and other brain functions. The development of human MAO inhibitors led to important breakthroughs in the therapy of several neuropsychiatric disorders. Different families of heterocycles containing 2 or 4 nitrogen atoms have been used as scaffolds for synthesizing selective monoamine oxidase inhibitors, but the early period of the MAO-inhibitors started with hydrazine derivatives. Pyrazole, pyrazoline, and pyrazolidine derivatives can be considered as a cyclic hydrazine moiety. This scaffold also displayed promising antidepressant and anticonvulsant properties as demonstrated by different and established animal models. Diversely substituted pyrazoles, embedded with a variety of functional groups, are important biological agents and a significant amount of research activity has been directed towards this chemical class.

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Section: Pyrazolidine Derivativesmentioning

confidence: 99%

Section: Pyrazoline Derivatives As Antidepressant and Anticonvulsant mentioning

confidence: 99%

The State of the Art of Pyrazole Derivatives as Monoamine Oxidase Inhibitors and Antidepressant/Anticonvulsant Agents

Secci

Bolasco²,

Chimenti³

et al. 2011

CMC

103

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“…( ( 3a,pyrazol-1(6aH)-yl)(phenyl)methanone (6a) F NMR spectra and the HRMS data of compounds 3, 5 and 6; X-ray Structure data of syn-3a (CCDC: 1570212) and anti-3a (CCDC: 1570213). The Supporting Information is available free of charge via the Internet at http://sioc-journal.cn/.…”

Section: General Procedures For the Synthesis Ofmentioning

confidence: 99%

A Facile Synthesis of CF₃-Substituted Pyrazolidines and Pyrazolines

Liu¹,

Huang²,

Wang³

et al. 2018

Chin. J. Org. Chem.

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“…2b,9a,b,10 On the other hand, as one of the five membered 1,2-dinitrogen heterocycles, pyrazolidine is an attractive subunit that exists in a broad range of biologically and pharmaceutically relevant compounds. 11 Many pyrazolidine derivatives possess high potential bioactivities such as antidepressants, 12 anesthetics 13 analgesic agents, 14 anticonvulsant activities, 15 antitumor, 16 and antimicrobial agents 17 ( Figure 1). However, in contrast to their analogues such as trifluoromethylated pyrazolines 18 and pyrazoles, 19 the reports on synthetic methods and bioactivity studies on trifluoromethylated pyrazolidines are formidably scarce in literature although many reports on the synthesis of non-trifluoromethylated pyrazolidines have appeared.…”

mentioning

confidence: 99%

[3+2] Cycloaddition of Trifluoromethylated N-Acylhydrazones with Maleates: Synthesis of Trifluoromethylated Pyrazolidines

et al. 2018

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An efficient [3+2] cycloaddition reaction of trifluoromethylated N-acylhydrazones with dimethyl maleate has been developed under basic conditions. This protocol provides an easy access to potentially bioactive trifluoromethylated pyrazolidines in moderate to excellent yields. It also illustrates that the trifluoromethylated N-acylhydrazones are useful trifluoromethyl building blocks for the synthesis of trifluoromethylated N-heterocycles.

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Synthesis and Screening of Cyclic Benzylhydrazine Congeners as Antidepressants

Cited by 9 publications

References 12 publications

The State of the Art of Pyrazole Derivatives as Monoamine Oxidase Inhibitors and Antidepressant/Anticonvulsant Agents

The State of the Art of Pyrazole Derivatives as Monoamine Oxidase Inhibitors and Antidepressant/Anticonvulsant Agents

A Facile Synthesis of CF₃-Substituted Pyrazolidines and Pyrazolines

[3+2] Cycloaddition of Trifluoromethylated N-Acylhydrazones with Maleates: Synthesis of Trifluoromethylated Pyrazolidines

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Synthesis and Screening of Cyclic Benzylhydrazine Congeners as Antidepressants

Cited by 9 publications

References 12 publications

The State of the Art of Pyrazole Derivatives as Monoamine Oxidase Inhibitors and Antidepressant/Anticonvulsant Agents

The State of the Art of Pyrazole Derivatives as Monoamine Oxidase Inhibitors and Antidepressant/Anticonvulsant Agents

A Facile Synthesis of CF3-Substituted Pyrazolidines and Pyrazolines

[3+2] Cycloaddition of Trifluoromethylated N-Acylhydrazones with Maleates: Synthesis of Trifluoromethylated Pyrazolidines

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A Facile Synthesis of CF₃-Substituted Pyrazolidines and Pyrazolines