2017
DOI: 10.1007/s11172-017-1914-5
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Synthesis and search for compounds with hemostatic activity in the series of 4-(het)aryl-4-oxobut-2-enoic acid derivatives

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Cited by 12 publications
(3 citation statements)
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“…1 Н NMR spectrum (400 MHz, CDCl 3 ), δ, ppm: 1.10 s (9Н, t-Bu), 5.52 s (2Н, СН 2 ), 5.54 s (1Н, СН), 7. 24 When conducting experiments on animals, the rules of laboratory practices and the requirements of ethics were observed.…”
Section: -Nitrobenzyl 2-[2-(diphenylmethylene)hydrazinyl]-55-dimethyl-4-oxohex-2-enoate (2o)mentioning
confidence: 99%
See 1 more Smart Citation
“…1 Н NMR spectrum (400 MHz, CDCl 3 ), δ, ppm: 1.10 s (9Н, t-Bu), 5.52 s (2Н, СН 2 ), 5.54 s (1Н, СН), 7. 24 When conducting experiments on animals, the rules of laboratory practices and the requirements of ethics were observed.…”
Section: -Nitrobenzyl 2-[2-(diphenylmethylene)hydrazinyl]-55-dimethyl-4-oxohex-2-enoate (2o)mentioning
confidence: 99%
“…It is important to note that the moiety of 2,4-dioxobutanoic acid, which persists in the structure of imino-and hydrazonofuranones conversion products, is a signifi cant pharmacophore fragment that confi rms the inexhaustible interest in the fi eld of medicinal chemistry. The derivatives of 2,4-dioxobutanoic acids have a range of biological activity, such as hemostatic [24], redox [25], antimicrobial [26,27], including against multi-resistant strains [28], antiviral [29][30][31][32][33][34][35][36][37][38][39][40][41][42], antifungal [43], analgesic [44], anti-infl ammatory [45], reparation with respect to damaged DNA sites [46], inhibiting proteintithosinphospotases [47] associated with many diseases, including cancer, diabetes, and autoimmune processes. All this makes this type of structure promising for synthesis and learning.…”
Section: Introductionmentioning
confidence: 99%
“…Как известно, N замещенные гидразиды 4 оксобут 2 еновых кислот, имеющие различные фармакофоры, в том числе адамантил, проявляют высокое био логическое действие при низкой острой ток сичности [2,3]. Для повышения биологической доступности и расширения спектра фармако логических испытаний нами впервые предло жен способ получения водорастворимых 4 (гет)арил 2 {2 [2 (адамантан 1 ил) 2 оксоэтили ден]гидразинил} 4 оксобут 2 еноатов натрия, обладающих высокой гемостатической и про тивомикробной активностью [4,5]. Однако анальгетическая и противовоспалительная ак тивность данных соединений ранее не изуча лась.…”
Section: Introductionunclassified