“…It is important to note that the moiety of 2,4-dioxobutanoic acid, which persists in the structure of imino-and hydrazonofuranones conversion products, is a signifi cant pharmacophore fragment that confi rms the inexhaustible interest in the fi eld of medicinal chemistry. The derivatives of 2,4-dioxobutanoic acids have a range of biological activity, such as hemostatic [24], redox [25], antimicrobial [26,27], including against multi-resistant strains [28], antiviral [29][30][31][32][33][34][35][36][37][38][39][40][41][42], antifungal [43], analgesic [44], anti-infl ammatory [45], reparation with respect to damaged DNA sites [46], inhibiting proteintithosinphospotases [47] associated with many diseases, including cancer, diabetes, and autoimmune processes. All this makes this type of structure promising for synthesis and learning.…”