Synthesis and selective M-cholinoblocking activity of tetraamines. Part II

1997 amines amines (benzene compounds) Q 0120 46 -104 Synthesis and Selective M-Cholinoblocking Activity of Tetramines. Part 2. -A variety of new tetramines such as (I) and (II) are synthesized and evaluated for their in vitro cholinoblocking activity. Derivatives (Ia) and (IIc) possess M2-receptor blocking selectivity comparable to metoctramin (IIa). -(BESPALOV, A. YA.; GORCHAKOVA, T. L.; DOLGO-SABUROV, V. B.; KUZNETSOV, S. G.; KOSMACHEV, A. B.; LIBMAN, N. M.; PODOSI-NOVIKOVA, N. P.; RAMSH, S. M.; SHELKOVNIKOV, S. A.; Khim.-Farm. Zh. 31 (1997) 7, 28-31; Inst. toksikol. Minzdravmedproma Rossii, St. Petersburg, Russia; RU)

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ChemInform Abstract: Synthesis and Selective M‐Cholinoblocking Activity of Tetramines. Part 2.

Bespalov¹,

Gorchakova²,

Dolgo‐Saburov³

et al. 1997

ChemInform

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Synthesis and selective M-cholinoblocking activity of tetraamines. Part II

Abstract: In the previous communication [I ] we have described an original method for the synthesis of tetraamines of type I, in which the methylene groups in radical B are partly replaced by aromatic fragments:RI_.CHzAr.

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ChemInform Abstract: Synthesis and Selective M‐Cholinoblocking Activity of Tetramines. Part 2.

ChemInform Abstract: Synthesis and Selective M‐Cholinoblocking Activity of Tetramines. Part 2.

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