Synthesis and Self-Assembly of Block Copolymers

Chenkual, Laltanpuii; Lalchandani, Dimple S.; Padakanti, Amruta Prabhakar; Chella, Naveen; Porwal, Pawan Kumar

doi:10.1007/978-981-99-6917-3_4

Block Co-Polymeric Nanocarriers: Design, Concept, and Therapeutic Applications 2023

DOI: 10.1007/978-981-99-6917-3_4

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Synthesis and Self-Assembly of Block Copolymers

Laltanpuii Chenkual,

Dimple S. Lalchandani,

Amruta Prabhakar Padakanti

et al.

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2024

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Cited by 2 publications

References 119 publications

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Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

Nath,

Dubey,

Kumar

et al. 2024

Journal of Lipids

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Topical drug delivery employing drug nanocarriers has shown prominent results in treating topical ailments, especially those confined to the skin and eyes. Conventional topical formulations persist with drug and disease‐related challenges during treatment. Various nanotechnology‐driven approaches have been adopted to mitigate the issues associated with conventional formulations. Among these, cubosomes have shown potential applications owing to their liquid crystalline structure, which aids in bioadhesion, retention, sustained release, and loading hydrophilic and hydrophobic moieties. The phase transition behavior of glyceryl monooleate, the concentration of stabilizers, and critical packing parameters are crucial parameters that affect the formation of cubosomes. Microfluidics‐based approaches constitute a recent advance in technologies for generating stable cubosomes. This review covers the recent topical applications of cubosomes for treating skin (psoriasis, skin cancer, cutaneous candidiasis, acne, and alopecia) and eye (fungal keratitis, glaucoma, conjunctivitis, and uveitis) diseases. The article summarizes the manufacturing and biological challenges (skin and ocular barriers) that must be considered and encountered for successful clinical outcomes. The patented products are successful examples of technological advancements within cosmeceuticals that support various topical applications with cubosomes in the pharmaceutical field.

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Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

Nath,

Dubey,

Kumar

et al. 2024

Journal of Lipids

View full text Add to dashboard Cite

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Patterns of Nanoporous Spherical Packing Emerging under Influence of Curvature and Confinement

Muhammad Javed Iqbal,

Inayatullah Soomro,

Usama Gulzar

2024

VFAST trans. math.

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Nanoporous membranes are popular in nanotechnology due to biomedical and industrial applications. During the past decade, experimental, theoretical and computational research into porous membranes and soft materials has opened up new mathematical dimensions. In bulk, diblock copolymers exhibit ordered morphologies such as parallel matrices of lamellae, bicontinuous matrices of gyroids, hexagonal matrices of cylinders and body-centred cubic matrices of spheres. In melt, confinement plays an essential role in tuning the frustration of the diblock copolymer system to predict more nanostructures. These nanostructures depend on the composition of the copolymers, their confining geometries and the degree of structural frustration. An isotropic 9-point stencil for Laplacian is constructed. The discrete finite-difference technique is used in polar grids to discretize the macromolecule of the diblock copolymer system to study spherical patterns to study the effect of curvature and confinement with a well-known and efficient cell dynamic simulation model. Intel FORTRAN (IFORT) codes are generated to run the CDS model and visualisation of simulation results is observed with the help of OPENDX. A comparison of the proposed study with existing experimental and computational studies is also presented.

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Synthesis and Self-Assembly of Block Copolymers

Cited by 2 publications

References 119 publications

Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

Patterns of Nanoporous Spherical Packing Emerging under Influence of Curvature and Confinement

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