Synthesis and Silica-Based Immobilization of Monofunctionalized Heptakis(2,6-di-O-methyl-3-O-pentyl)-β-cyclodextrin for Enantioselective Capillary-HPLC

Dittmann, Helmutt; König, Wilfried Α.

doi:10.1002/1521-4168(20001001)23:10<583::aid-jhrc583>3.0.co;2-4

Cited by 8 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently monolithic capillary chiral stationary phases have been developed to overcome the problems in the preparation of packed capillary/nanocolumns, but their development is still in cradle . In literature, the use of the packed version of chiral columns, with nano and capillary dimensions, is mainly reported . Beside the development of hardware miniaturization, in the last 10 years, there has been an impressive evolution in terms of particle design leading to ultrafast separations without loss of efficiency and resolution.…”

Section: Performance Screening Of Nano‐ss‐whelk‐o1–25 and 5‐csps Colmentioning

confidence: 99%

Toward enantioselective nano ultrahigh‐performance liquid chromatography with Whelk‐O1 chiral stationary phase

et al. 2014

View full text Add to dashboard Cite

In this study, a Whelk-O1 chiral stationary phase immobilized on 2.5 μm silica particles was employed in nanoLC. Two nanocolumns (180 and 250 mm long, 75 μm id) with a single polymeric organic monolithic outlet frit were packed under high-pressure ultrasonic-assisted packing procedure. The monolithic outlet frit was prepared by thermal polymerization of methacrylate-based monomers affording high-mechanical stability and high-pressure resistance. Very efficient enantioseparations with more than 70 000 plates/m were achieved in normal phase mode by eluting (+/-) acenaphthenol. Nanocolumns were also tested in RP mode by using on-line MS detection with nano-spray ESI ion source. Kinetic performances of columns in RP mode were comparable to those in normal phase-conditions.

show abstract

Section: Performance Screening Of Nano‐ss‐whelk‐o1–25 and 5‐csps Colmentioning

confidence: 99%

Toward enantioselective nano ultrahigh‐performance liquid chromatography with Whelk‐O1 chiral stationary phase

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Solid-phase microextraction combined with GC/MS and enantioseparation on a CD CSP in HPLC was used to profile chiral aroma compounds in flavored alcoholic beverages (wine coolers) (130). Monofunctionalized heptakis(2,6di-O-methyl-3-O-pentyl)-β-CD was synthesized and immobilized to commercially available aminopropyl silica, resulting in a lipophilic CSP for enantioseparations in capillary HPLC using reversedphase conditions (131).…”

Section: High-performance Liquid Chromatographymentioning

confidence: 99%

Chiral Separations

Ward

2002

Anal. Chem.

123

View full text Add to dashboard Cite

Preparation and enantioseparation characteristics of two chiral stationary phases based on mono(6^A‐azido‐6^A‐deoxy)‐perphenylcarbamoylated α‐ and γ‐cyclodextrin

Lai

Bai

et al. 2004

Chirality

View full text Add to dashboard Cite

Two chiral stationary phases, ph-alpha-CD and ph-gamma-CD, were prepared from mono(6(A)-azido-6(A)-deoxy)perphenylcarbamoylated alpha- and gamma-cyclodextrin immobilized onto silica gel via the Staudinger reaction. The chromatographic characteristics of these two chiral stationary phases were evaluated. The influence of different cyclodextrins (CDs) on the enantioselectivities was also investigated in this study. Compared to ph-gamma-CD, ph-alpha-CD exhibited quite good enantioselectivity toward the analytes with bulky molecular structures. It was found that the formation of inclusion complex might play a quite important role in the chiral recognition not only under reverse phases but also under normal phases.

show abstract

Synthesis and Silica-Based Immobilization of Monofunctionalized Heptakis(2,6-di-O-methyl-3-O-pentyl)-β-cyclodextrin for Enantioselective Capillary-HPLC

Cited by 8 publications

References 31 publications

Toward enantioselective nano ultrahigh‐performance liquid chromatography with Whelk‐O1 chiral stationary phase

Toward enantioselective nano ultrahigh‐performance liquid chromatography with Whelk‐O1 chiral stationary phase

Chiral Separations

Preparation and enantioseparation characteristics of two chiral stationary phases based on mono(6^A‐azido‐6^A‐deoxy)‐perphenylcarbamoylated α‐ and γ‐cyclodextrin

Contact Info

Product

Resources

About

Synthesis and Silica-Based Immobilization of Monofunctionalized Heptakis(2,6-di-O-methyl-3-O-pentyl)-β-cyclodextrin for Enantioselective Capillary-HPLC

Cited by 8 publications

References 31 publications

Toward enantioselective nano ultrahigh‐performance liquid chromatography with Whelk‐O1 chiral stationary phase

Toward enantioselective nano ultrahigh‐performance liquid chromatography with Whelk‐O1 chiral stationary phase

Chiral Separations

Preparation and enantioseparation characteristics of two chiral stationary phases based on mono(6A‐azido‐6A‐deoxy)‐perphenylcarbamoylated α‐ and γ‐cyclodextrin

Contact Info

Product

Resources

About

Preparation and enantioseparation characteristics of two chiral stationary phases based on mono(6^A‐azido‐6^A‐deoxy)‐perphenylcarbamoylated α‐ and γ‐cyclodextrin