Synthesis and Solution Properties of Double Hydrophilic Poly(ethylene oxide)-block-poly(2-ethyl-2-oxazoline)  (PEO-b-PEtOx) Star Block Copolymers

Rudolph, Tobias; Crotty, Sarah; Lühe, Moritz von der; Pretzel, David; Schubert, Ulrich S.; Schacher, Felix H.

doi:10.3390/polym5031081

Cited by 26 publications

(18 citation statements)

References 66 publications

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“…Aggregates with hydrodynamic radii of 104 nm were observed for PEO 107 ‐ b ‐PMeOx 64 and 270 nm for PEO 107 ‐ b ‐PMeOx 112 , respectively. Schacher and co‐workers observed aggregation of PEO‐ b ‐poly(2‐ethyl‐2‐oxazoline) (PEO‐ b ‐PEtOx) eight‐arm star polymers in aqueous solution . Turbid solutions were obtained that contained polymer particles with hydrodynamic radii of several hundred nm even at concentrations below 0.5 g L −1 .…”

Section: Double Hydrophilic Block Copolymer Systems For Self‐assemblymentioning

confidence: 99%

Double Hydrophilic Block Copolymer Self‐Assembly in Aqueous Solution

Schmidt

2018

Macro Chemistry & Physics

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Self‐assembly of double hydrophilic block copolymers (DHBCs) in water is an emerging area of research. The self‐assembly process can be derived from aqueous two‐phase systems that are composed of hydrophilic homopolymers at elevated concentration. Consecutively, DHBCs form self‐assembled structures like micelles, vesicles, or particles at high concentrations in water and without the use of external triggers that would change solubility of individual blocks. Careful choice of the two hydrophilic blocks and design of the polymer structure allows formation of self‐assembled structures with high efficiency. The present contribution highlights recent research in the area of DHBC self‐assembly, including the polymer types employed and strategies for crosslinking of the self‐assembled structures. Moreover, an overview of aqueous multiphase systems and theoretical considerations of DHBC self‐assembly are presented, as well as an outlook regarding potential future applications in areas such as the biomedical field.

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Section: Double Hydrophilic Block Copolymer Systems For Self‐assemblymentioning

confidence: 99%

Double Hydrophilic Block Copolymer Self‐Assembly in Aqueous Solution

Schmidt

2018

Macro Chemistry & Physics

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“…Furthermore, Rudolph et al showed that MALDI, static light scattering (SLS) and 2D-LC are essential to obtain absolute molar masses, and to confirm the architecture of their star-shaped [PEO -b-PEtOx] , which was synthesized by the coppercatalyzed azide-alkyne cycloaddition reaction (CuAAC). These techniques are necessary considering that NMR spectroscopy and SEC are not satisfactory to fully characterize these systems [126].…”

Section: Star-shaped Polymersmentioning

confidence: 99%

Polymer architectures via mass spectrometry and hyphenated techniques: A review

Crotty

Gerişlioğlu

Endres

et al. 2016

Analytica Chimica Acta

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This review covers the application of mass spectrometry (MS) and its hyphenated techniques to synthetic polymers of varying architectural complexities. The synthetic polymers are discussed as according to their architectural complexity from linear homopolymers and copolymers to stars, dendrimers, cyclic copolymers and other polymers. MS and tandem MS (MS/MS) has been extensively used for the analysis of synthetic polymers. However, the increase in structural or architectural complexity can result in analytical challenges that MS or MS/MS cannot overcome alone. Hyphenation to MS with different chromatographic techniques (2D × LC, SEC, HPLC etc.), utilization of other ionization methods (APCI, DESI etc.) and various mass analyzers (FT-ICR, quadrupole, time-of-flight, ion trap etc.) are applied to overcome these challenges and achieve more detailed structural characterizations of complex polymeric systems. In addition, computational methods (software: MassChrom2D, COCONUT, 2D maps etc.) have also reached polymer science to facilitate and accelerate data interpretation. Developments in technology and the comprehension of different polymer classes with diverse architectures have significantly improved, which allow for smart polymer designs to be examined and advanced. We present specific examples covering diverse analytical aspects as well as forthcoming prospects in polymer science.

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“…48 In a similar approach, star polymers have been prepared starting from azido-functionalized β-cyclodextrin. 33 However, conjugation of hydrophilic PAOx (PMeOx or PEtOx) with hydrophobic polymer blocks offers even more possibilities towards complex architectures due to microphase segregation of immiscible polymer segments.…”

Section: Applications Of Chain-end Clickable Poly(2-oxazoline)smentioning

confidence: 99%

Poly(2-oxazoline)s and click chemistry: A versatile toolbox toward multi-functional polymers

Lava

Verbraeken

Hoogenboom

2015

European Polymer Journal

134

105

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Poly(2-alkyl/aryl-2-oxazoline)s (PAOx) have been gaining increasing attention because they combine biocompatibility with so-called stealth behavior, making them ideal candidates for use in a wide variety of biomedical applications. Especially, the possibility of side-chain modification makes them a valuable alternative to poly(ethylene glycol), currently the gold standard amongst biocompatible polymers. Nevertheless, the cationic ring opening polymerization of 2-oxazolines is not compatible with nucleophilic entities, for example hydroxyl and amine moieties. Therefore, the modular approach of 'click chemistry' offers an elegant strategy towards functional PAOx by postpolymerization modification of PAOx that contain clickable groups. This feature describes the synthesis of PAOx with such clickable entities at the chain-end or in the side-chain, as well as their potential (bio)materials applications.

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Synthesis and Solution Properties of Double Hydrophilic Poly(ethylene oxide)-block-poly(2-ethyl-2-oxazoline) (PEO-b-PEtOx) Star Block Copolymers

Cited by 26 publications

References 66 publications

Double Hydrophilic Block Copolymer Self‐Assembly in Aqueous Solution

Double Hydrophilic Block Copolymer Self‐Assembly in Aqueous Solution

Polymer architectures via mass spectrometry and hyphenated techniques: A review

Poly(2-oxazoline)s and click chemistry: A versatile toolbox toward multi-functional polymers

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