Synthesis and Some Properties of 2-Amino-4-aryl-6-hexyl-7-hydroxy-4H-chromene-3-carbonitriles

Dotsenko, V. V.; Khalatyan, Karina V.; Russkikh, A. A.; Varzieva, E. A.; Kramareva, D. A.; Vasilin, V. K.; Аксенов, Н. А.; Аксенова, И. В.

doi:10.1134/s1070363222120374

Cited by 2 publications

(3 citation statements)

References 55 publications

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“…Adduct [C], followed by intramolecular cyclization and 1,3-proton shift, yields the title compound ACC [61,62]. FTIR, 1 H-NMR, 13 C-NMR, and MS spectra were used to describe the end products.…”

Section: Entrymentioning

confidence: 99%

“…4 H ‐Chromene scaffold possesses anti‐inflammatory [5], antibacterial [6, 7], antifungal [8], antitumor [9], antioxidant [7], antileishmanial [10], and anticancer [11, 12], making it an attractive platform for drug discovery. The efficient synthesis of ACC, therefore, garnered significant interest in the scientific community [13]. Traditional synthesis methods for ACC often involve the use of volatile solvents, low yields, complex reaction conditions, significant waste generation, and lengthy procedures [14–17].…”

Section: Introductionmentioning

confidence: 99%

“…4H-Chromene scaffold possesses antiinflammatory [5], antibacterial [6,7], antifungal [8], antitumor [9], antioxidant [7], antileishmanial [10], and anticancer [11,12], making it an attractive platform for drug discovery. The efficient synthesis of ACC, therefore, garnered significant interest in the scientific community [13].…”

Section: Introductionmentioning

confidence: 99%

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2‐Aminopyrazine catalyzed three‐component and one‐pot construction of 2‐amino‐4H‐chromene‐3‐carbonitrile by mortar‐pestle grinding and molecular docking studies

Edapu,

Boodida,

Pagadala

et al. 2024

J Chinese Chemical Soc

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A highly efficient and environmentally friendly method for the synthesis of 2‐amino‐4H‐chromene‐3‐carbonitrile (ACC) derivatives has been successfully established. This innovative, solvent‐free approach involves a tandem three‐component and one‐pot reaction utilizing arylaldehyde, dicyanomethane, and dimedone/cyclohexane‐1,3‐dione, catalyzed by 2‐aminopyrazine under the mortar‐pestle grinding technique. Key attributes of this synthetic strategy include its simplicity, high efficiency, cost‐effectiveness, absence of column chromatography, shorter reaction times (18–40 min), and consistently high yields (89%–96%). Furthermore, computational studies have been conducted against the 4RHT protein using the synthesized compounds.

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Section: Entrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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2‐Aminopyrazine catalyzed three‐component and one‐pot construction of 2‐amino‐4H‐chromene‐3‐carbonitrile by mortar‐pestle grinding and molecular docking studies

Edapu,

Boodida,

Pagadala

et al. 2024

J Chinese Chemical Soc

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The chemistry of heterocycles in the 21st century

Charushin,

Verbitskiy,

Chupakhin

et al. 2024

RUSS CHEM REV

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The chemistry of heterocyclic compounds has traditionally been and remains a bright area of chemical science in Russia. This is due to the fact that many heterocycles find the widest application. These compounds are the key structural fragments of most drugs, plant protection agents. Many natural compounds are also derivatives of heterocycles. At present, more than half of the hundreds of millions of known chemical compounds are heterocycles. This collective review is devoted to the achievements of Russian chemists in this field over the last 15–20 years. The review presents the achievements of leading heterocyclists representing both RAS institutes and university science. It is worth noting the wide scope of the review, both in terms of the geography of author teams, covering the whole of our large country, and in terms of the diversity of research areas. Practically all major types of heterocycles are represented in the review. The special attention is focused on the practical applications of heterocycles in the design of new drugs and biologically active compounds, high-energy molecules, materials for organic electronics and photovoltaics, new ligands for coordination chemistry, and many other rapidly developing areas. These practical advances would not be possible without the development of new fundamental transformations in heterocyclic chemistry.<br> Bibliography — 2237 references.

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Synthesis and Some Properties of 2-Amino-4-aryl-6-hexyl-7-hydroxy-4H-chromene-3-carbonitriles

Cited by 2 publications

References 55 publications

2‐Aminopyrazine catalyzed three‐component and one‐pot construction of 2‐amino‐4H‐chromene‐3‐carbonitrile by mortar‐pestle grinding and molecular docking studies

2‐Aminopyrazine catalyzed three‐component and one‐pot construction of 2‐amino‐4H‐chromene‐3‐carbonitrile by mortar‐pestle grinding and molecular docking studies

The chemistry of heterocycles in the 21st century

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