Synthesis and Spectral Analysis of an Array of Novel 4-(4-Morpholinophenyl)-6-Aryl-Pyrimidin-2-Amines

Abstract

An array of newly synthesized novel 4-(4-morpholinophenyl)-6-arylpyrimidin-2-amines (20-28) are synthesized from the respective (E)-1-4-morpholinophenyl)-3-aryl-prop-2-en-1-ones (11-19) by the treatment of guanidine nitrate in refluxing ethanol catalyzed by lithium hydroxide and characterized by melting point, elemental analysis, MS, FT-IR, one-dimensional NMR ( 1 H & 13 C) spectroscopic data.