Synthesis and Spectral Characterization of 14- and 16-membered tetraazamacrocyclic Schiff base ligands and their transition metal complexes and a comparative study of interaction of calf thymus DNA with copper(II) complexes

Khan, Tabreiz Ahmad; Naseem, Swaleha; Khan, Shahper N.; Khan, Asad; Shakir, Mohammad

doi:10.1016/j.saa.2009.03.022

Cited by 58 publications

(22 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Electronic absorption spectroscopy has been widely employed to determine the binding ability of metal complexes with DNA [87][88][89][90]. The binding ability of the synthesized oxovanadium(IV) complexes [(L 1 )VO]Á 4H 2 O (1) and [(L 2 )VO]Á 3H 2 O (9) with HS-DNA was investigated by measuring the spectral changes of their electronic spectra during the interaction with DNA.…”

Section: Electronic Spectral Studiesmentioning

confidence: 99%

“…To compare quantitatively the affinity of the two complexes toward DNA, the binding constants K b of the two complexes to HS-DNA were determined by monitoring the changes of absorbance at 221 nm for the complexes, with increasing concentration of DNA. The appreciable decrease in absorption intensity and red shift of the k max band suggest that the complexes bind to DNA strongly [87][88][89][90]95]. From the absorption titration data, the binding constant (K b ) was determined using the following equation [96]: [97,98] and revealed that complex 9 shows a stronger binding ability toward DNA which may be due to the presence of an appending aromatic moiety in H 2 L 2 ligand and thus the larger binding affinity of the corresponding complex 9 in comparison with complex 1 incorporating H 2 L 1 ligand [35,[99][100][101].…”

Section: Electronic Spectral Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Shebl

Khalil

2014

Monatsh Chem

View full text Add to dashboard Cite

Two pentadentate carbohydrazone ligands, H 2 L 1 and H 2 L 2 , were prepared by the reaction of the bifunctional compound carbohydrazide with 2-hydroxy-5-nitrobenzaldehyde and 2-hydroxy-1-naphthaldehyde, respectively. Reactions of the ligands with oxovanadium(IV), cerium(III), thorium(IV), and dioxouranium(VI) ions yielded binary complexes. Reactions of the ligands with the dioxouranium(VI) ion in the presence of secondary ligands (8-hydroxyquinoline, glycine, salicylaldehyde, or benzoylacetone) yielded ternary complexes. The ligands and metal complexes were characterized by different techniques such as elemental and thermal analyses, IR, 1 H and 13 C NMR, electronic, ESR, mass spectra, and powder XRD as well as magnetic susceptibility and conductivity measurements. The coordinating sites are phenolic oxygen, azomethine nitrogen, and carbonyl oxygen. In complexes, the ligands act as dibasic pentadentate except ternary dioxouranium(VI) complexes, obtained using glycine or benzoylacetone, in which the ligands act as monobasic pentadentate. The XRD patterns for the H 2 L 1 ligand, its binary dioxouranium(VI) complex, and its 8-hydroxyquinoline ternary complex indicate crystalline nature and the grain size was estimated. The H 2 L 1 ligand and its binary complex have triclinic systems while the ternary complex has a monoclinic system with different unit-cell parameters. The ligands and some of their metal complexes showed antimicrobial activity toward some Gram-positive and Gram-negative bacteria, yeast (Candida albicans), and fungus (Aspergillus fumigatus), and MIC values were determined. The DNA binding properties of the oxovanadium(IV) complexes of H 2 L 1 and H 2 L 2 ligands were investigated by electronic absorption spectroscopy and viscosity measurements. The results indicated that these complexes bind to DNA via an intercalation binding mode with an intrinsic binding constant K b of 2.55 9 10 4 and 3 9 10 4 M -1 , respectively.

show abstract

Section: Electronic Spectral Studiesmentioning

confidence: 99%

Section: Electronic Spectral Studiesmentioning

confidence: 99%

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Shebl

Khalil

2014

Monatsh Chem

View full text Add to dashboard Cite

show abstract

“…Another band which appeared in the region 3210-3220 cm À1 may be ascribed [27] to the coordinated NAH stretching vibrations of pyrrole ring. A weak absorption band in the region 2810-2815 cm À1 may be assigned to the CH 3 stretching vibration [16]. The bands appearing in the regions 2910-2920 cm À1 and 1440-1465 cm À1 in all complexes may be due to m(CAH) and d(CAH), respectively [16].…”

Section: Ir Spectramentioning

confidence: 97%

“…It has been suggested that the azomethine linkage is responsible for the biological activities of Schiff bases such as, antitumour, antibacterial, antifungal and herbicidal activities [11,14]. We have a long term interest in synthesis and characterization of transition metal complexes of a wide variety [15][16][17] and recently also studies their biological properties [18][19][20][21]. Herein, we report the Schiff base complexes, MLCl 2 [M = Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)] which were also studied for their antimicrobial properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antimicrobial studies of Schiff base complexes

Zafar

Ahmad

Khan

et al. 2015

Journal of Molecular Structure

Self Cite

View full text Add to dashboard Cite

“…The g av is related to g ll and g ┴ by the equation g av = (g ll -2) / (g ┴ -2) and is calculated to be 2.5. Since the value of g ll is less than 2.5 then the complex possesses considerable covalent character in the metal ligand bond 12 .…”

Section: Esr Spectramentioning

confidence: 99%

Synthesis, Characterization and Biological Activities of a New 5-Chloroisatin Schiff Base and its Metal Complexes

2013

Chem Sci Trans

View full text Add to dashboard Cite

Copper (II), cobalt (II), nickel (II) and zinc (II) complexes of 5-chloroisatin Schiff base (L)(L= Schiff base derived from 5-chloroisatin and 2-methyl-4-nitro aniline) were synthesized and characterized. The authenticity of the ligand and its metal complexes had been established by micro analysis, IR, NMR, LC/MS, UV-Vis and electrical conductance measurements. The ligand acts as a bidentate in which the carbonyl oxygen and the azomethine nitrogen of 5-chloroisatin are involved in co-ordination. Square planar geometry was proposed for Cu(II) and Ni(II) complexes and tetrahedral geometry was proposed for Co(II) and Zn(II) complexes. The ligand and its metal complexes have been screened for their antibacterial activity against bacterias viz. Staphylococcus aureus and Escherichia coli etc. and antifungal activity against fungi Aspergillus niger and Aspergillus flavous etc. The activities of both the samples have shown significant and noticeable changes on complexations.

show abstract

Synthesis and Spectral Characterization of 14- and 16-membered tetraazamacrocyclic Schiff base ligands and their transition metal complexes and a comparative study of interaction of calf thymus DNA with copper(II) complexes

Cited by 58 publications

References 28 publications

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Synthesis, characterization and antimicrobial studies of Schiff base complexes

Synthesis, Characterization and Biological Activities of a New 5-Chloroisatin Schiff Base and its Metal Complexes

Contact Info

Product

Resources

About