Synthesis and Spectral Characterization Studies of New Trimethoprim-Diphenylphosphate Metal Complexes

doi:10.21275/v5i1.nov152999

IJSR

2016

DOI: 10.21275/v5i1.nov152999

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Synthesis and Spectral Characterization Studies of New Trimethoprim-Diphenylphosphate Metal Complexes

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Cited by 2 publications

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In situ methanolic solvent synthesis, spectroscopic and thermogravimetric characterizations of three new transition metal complexes of trimethoprim drug

Refat

Al‐Humaidi

El‐Sayed

et al. 2021

Polish Journal of Chemical Technology

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Trimethoprim drug (TMP) complexes of copper (II), cobalt (II), and nickel (II) were prepared and discussed by using elemental analysis (C, H, N analysis), magnetic, molar conductance, FTIR, Raman spectroscopy, electron spin resonance (ESR) and UV-vis spectroscopy analyses. TMP drug coordinated as a tridentate ligand towards the respected three metal ions through two nitrogen atoms of amino groups and nitrogen atom of pyrimidine ring which flanked between –NH2 groups, these assignments confirmed by spectroscopic, magnetic, ESR and thermogravimetric analyses with formulas [Cu(TMP)(H2O)3]Cl2, [Co(TMP)(H2O)3]Cl2 and [Ni(TMP) (H2O)]Cl2. Copper (II) and cobalt (II) complexes have an octahedral geometrical structure included one TMP molecule, three coordinated water molecules and two uncoordinated chlorine atoms while, nickel(II)–TMP complex has a tetrahedral geometric configuration that involved one TMP molecule, one coordinated water molecule and two uncoordinated chlorine atoms. The activation energies and other kinetic thermodynamic parameters were estimated based on the employed of the Coats-Redfern and Horowitz-Metzger equations. The nano–structured form of the synthesized TMP complexes was confirmed dependent on the transmission electron microscopy (TEM).

show abstract

In situ methanolic solvent synthesis, spectroscopic and thermogravimetric characterizations of three new transition metal complexes of trimethoprim drug

Refat

Al‐Humaidi

El‐Sayed

et al. 2021

Polish Journal of Chemical Technology

View full text Add to dashboard Cite

show abstract

Synthesis, Characterization, Antimalarial and Antimicrobial activities of Mixed Ibuprofen-Pyrimethamine M(II) Complexes [M = Cd, Co, Zn, Mn]

Bamigboye

Ejidike²

2019

Natural and Applied Sciences Journal

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Mixed complexes of Ibuprofen-Pyrimethamine were synthesized using Cd(II) Co(II), Zn(II), and Mn(II). The mixed complexes were characterized based on some physicochemical and spectroscopic techniques such as infrared, elemental analysis, conductivity measurements, and magnetic moment. Based on the results obtained, the complexes were formulated as [M(L1)(L2)]Cl2, where M = metal ion, L1 = Pyrimethamine, L2 = Ibuprofen). The complexes were found to be non-electrolytes. The ligands act as bidentate towards the central metal ions with deprotonation occurring at the carboxylic group. The complexes were also analyzed by conductometric titration. Antimicrobial screening against the selected organisms: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus substilis, Bacillus megaterium and Serratia marcescens for the complexes alongside the free ligands were investigated. The antimalarial study was investigated for the compounds against Plasmodium berghei (NK 65 strain). It was observed that the complexes showed significant potentials against the studied organisms.

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Synthesis and Spectral Characterization Studies of New Trimethoprim-Diphenylphosphate Metal Complexes

Cited by 2 publications

References 30 publications

In situ methanolic solvent synthesis, spectroscopic and thermogravimetric characterizations of three new transition metal complexes of trimethoprim drug

In situ methanolic solvent synthesis, spectroscopic and thermogravimetric characterizations of three new transition metal complexes of trimethoprim drug

Synthesis, Characterization, Antimalarial and Antimicrobial activities of Mixed Ibuprofen-Pyrimethamine M(II) Complexes [M = Cd, Co, Zn, Mn]

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