Synthesis and spectroscopic characterisation of novel bioactive molecule of 3-(2-substituted)-1H-indol-3-yl)-1-(thiophen-2yl)prop-2-en-1-one chalcone derivatives as effective anti-oxidant and anti-microbial agents

Gopi, Chandravadivelu; Sastry, V. Girija; Dhanaraju, Magharla Dasaratha

doi:10.1016/j.bjbas.2016.08.004

Cited by 12 publications

(5 citation statements)

References 17 publications

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“…Ferrocenyl chalcones have been altered to produce sulfones [25]. These sulphur-based compounds were synthesized using the meta-chloroperbenzoic acid, catalysed oxidation of ferrocenyl chalcone sulfides ( Figure 2).…”

Section: Ferrocenyl Chalconesmentioning

confidence: 99%

Ferrocenyl chalcone derivatives as possible antimicrobial agents

et al. 2020

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The swift spread of infections caused by drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), has quickly become a worldwide concern as infections spread from healthcare settings to the wider community. While ferrocenyl chalcones, which are chalcone derivatives with antimicrobial activity, have gained attention from researchers, further study is needed to assess their cytotoxicity. Ten newly developed chalcones, in which ring A was replaced with a ferrocenyl moiety and ring B contained increasing alkyl chain lengths from 5-10 carbons, were assessed. Using 2-fold broth microdilution, the minimum inhibitory concentration (MIC) of five of the ten compounds were lower against Gram-positive organisms (MICs from 0.008 mg/ml to 0.063 mg/ml) than Gram-negative organisms (MICs = 0.125 mg/ml). These novel ferrocenyl chalcone compounds were effective against 3 types of clinically isolated drug-resistant S. aureus, including a MRSA, and against other non-resistant clinically isolated and laboratory-adapted Gram-positive bacteria. The same compounds inhibited growth in non-resistant bacteria by potentially obstructing cellular respiration in Gram-positive bacteria. Images obtained through scanning electron microscopy revealed fully lysed bacterial cells once exposed to a selected compound that showed activity. The results indicate that these newly developed compounds could be important antimicrobial agents in the treatment of infections from clinically resistant bacteria.

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Section: Ferrocenyl Chalconesmentioning

confidence: 99%

Ferrocenyl chalcone derivatives as possible antimicrobial agents

et al. 2020

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“…The activity was done according to Gopi et al, [32] . Take a 2 ml DPPH methyl alcohol solution (25 µg/ ml) and mix with 0.5 ml seagrass extracts at various concentrations.…”

Section: Dpph Radical-scavenging Activitymentioning

confidence: 99%

Phytoconstituents Screening and Antioxidant Activity of Syringodium isoetifolium Leaf Extracts

Kavitha¹,

Padmini²,

Chandravadivelu³

et al. 2022

IJPS

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Kavitha et al.: Phytoconstituents and Antioxidant effect of SeagrassThis research aimed to explore the antioxidant potency of leaf extracts of Syringodium isoetifolium seagrass. In this study, seagrass leaves were collected from the local tribe's source, dried and extracted with water, alcohol, hydro alcohols, acetone and n-hexane. Phytochemical investigation on extracts was performed using chemical and gas chromatography-mass spectrometric techniques. It reveals that the extracts are enriched with pharmacologically active compounds such as phenol, polyphenol, alkaloid, glycoside, saponin, flavonoids, dicarboxylic acids and other constituents. Later, the crude extracts were estimated for antioxidant activity using different in vitro methods such as 2,2-diphenyl-1-picryl-hydrazyl-hydrate, total antioxidant, nitric oxide, superoxide anion and hydroxyl radical scavenging activities. The result demonstrated that the extracts exhibited higher radical scavenging activity as compared to the ascorbic acid. Among the different extracts, the hydroalcoholic extract had shown an excellent antioxidant activity due to the existence of more potent phytochemicals.

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“…After complete addition, the mixture again stirred for 2 h at 100°C. The separated product was washed with water, dried over anhydrous calcium chloride and recrystallised from hot ethanol [27].…”

Section: Preparation Of 1h-indole-3-carbaldehyde [1]mentioning

confidence: 99%

Synthesis and antioxidant properties of 2-(3-(hydroxyimino)methyl)-1H-indol-1-yl)acetamide derivatives

Gopi¹,

Dhanaraju²

2020

Futur J Pharm Sci

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Background The main aim of this work was to synthesise a novel N-(substituted phenyl)-2-(3-(hydroxyimino) methyl)-1H-indol-1-yl) acetamide derivatives and evaluate their antioxidant activity. These compounds were prepared by a condensation reaction between 1H-indole carbaldehyde oxime and 2-chloro acetamide derivatives. The newly synthesised compound structures were characterised by FT-IR, 1H-NMR, mass spectroscopy and elemental analysis. Furthermore, the above-mentioned compounds were screened for antioxidant activity by using ferric reducing antioxidant power (FRAP) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) methods. Result The antioxidant activity result reveals that most of the compounds were exhibiting considerable activity in both methods and the values are very closer to the standards. Among the synthesised compounds, compound 3j, 3a and 3k were shown remarkable activity at low concentration. Conclusion Compounds 3j, 3a and 3k were shown highest activity among the prepared analogues due to the attachment of halogens connected at the appropriate place in the phenyl ring. Hence, these substituted phenyl rings considered as a perfect side chain for the indole nucleus for the development of the new antioxidant agents.

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Synthesis and spectroscopic characterisation of novel bioactive molecule of 3-(2-substituted)-1H-indol-3-yl)-1-(thiophen-2yl)prop-2-en-1-one chalcone derivatives as effective anti-oxidant and anti-microbial agents

Cited by 12 publications

References 17 publications

Ferrocenyl chalcone derivatives as possible antimicrobial agents

Ferrocenyl chalcone derivatives as possible antimicrobial agents

Phytoconstituents Screening and Antioxidant Activity of Syringodium isoetifolium Leaf Extracts

Synthesis and antioxidant properties of 2-(3-(hydroxyimino)methyl)-1H-indol-1-yl)acetamide derivatives

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