Synthesis and spectroscopic properties of novel dipyrrole and tetrapyrrole-based photosensitizers with various biphenylyl substituents

Synthesis, Electrochemical and Photochemical Properties of Sulfanyl Porphyrazine with Ferrocenyl Substituents

“…Singlet oxygen is one of the main reactive oxygen species responsible for the cytotoxic effect of photodynamic therapy [ 32 , 33 ]. The comparative method was utilized for Φ Δ measurements with zinc(II) phthalocyanine as a reference and 1,3-diphenylisobenzofuran (DPBF) as a chemical quencher of singlet oxygen ( Figure 4 ) [ 34 , 35 ]. Pz 4 revealed a low ability for singlet oxygen generation, with Φ Δ values of 0.064 and 0.004 in DMF and DMSO, respectively ( Table 1 ).…”

“…The quantum yields of singlet oxygen generation (Φ Δ ) were determined by the relative chemical trapping method [ 34 , 35 , 49 ]. 1,3-Diphenylisobenzofuran (DPBF, Aldrich) was used as a chemical quencher for singlet oxygen, and zinc(II) phthalocyanine was a reference with known singlet oxygen generation quantum yields (Φ ΔDMF = 0.56; Φ ΔDMSO = 0.67) [ 50 ].…”

A Facile Method for Multigram Scale Light-Induced Synthesis of 4′-(Bromomethyl)-2-cyanobiphenyl

“…The biphenyl motif has gained much interest in the research and synthesis of a diverse array of specialty compounds such as different classes of pharmaceuticals, luminescent sensors and photosensitizers. − For pharmaceuticals, in particular, the 4′-(bromomethyl)-2-cyanobiphenyl intermediate ( 1 , Scheme ) has an important role in the commercial synthesis of the group of hypertensive drugs known as sartans. ,− But 1 has also gained use in the synthesis of, e.g., antihyperglycemic, anticancer, and wound healing drugs and PDE inhibitors, which spells a potential huge importance of 1 both in the development and production of new pharmaceutical compounds. − This is in addition to the importance of 1 in new production sites for the already commercialized derivative of 1 with expired patents.…”