Synthesis and spectroscopic studies of iron (III) complex with a quinolone family member (pipemidic acid)

Skrzypek, D.; Szymańska, Beata; Kovala‐Demertzi, Dimitra; Wiecek, Joanna; Talik, E.; Demertzis, Mavroudis A.

doi:10.1016/j.jpcs.2006.07.013

Cited by 24 publications

(10 citation statements)

References 31 publications

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“…In the case of the present iron(III) complex, the 6 A 1 ground state is spilt into three Kramer's doublets due to spin-orbit mixing with excited states. These doublets are split by an applied magnetic field and the near isotropic g-factor of 4.0 is assigned to a transition within one of them [43]. The ESR of ruthenium complex 21 was recorded at room temperature and the g values are given in table 6.…”

Section: Electron Spin Resonance Of Copper(ii) Nickel(ii) Cobalt(iimentioning

confidence: 99%

Synthesis and characterization of a hydrazone ligand containing antipyrine and its transition metal complexes

Fouda

Abd-Elzaher

Shakdofa

et al. 2008

Journal of Coordination Chemistry

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The coordination chemistry of N 0 -((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)methylene)-2-hydroxybenzohydrazide with copper(II), nickel(II), cobalt(II), manganese(II), zinc(II), palladium(II), iron(III), ruthenium(III), uranyl(VI), and titanium(IV) has been studied. The ligand and its complexes was characterized by elemental and thermal analyses, magnetic moments and conductivity measurements as well as spectroscopic techniques such as infrared, mass spectra, nuclear magnetic resonance, electron spin resonance and electronic absorption spectra. The spectral data showed that the ligand is monobasic tridentate coordinated via the enolic carbonyl oxygen of the hydrazide moiety, azomethine nitrogen and pyrazolone oxygen atoms.

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Section: Electron Spin Resonance Of Copper(ii) Nickel(ii) Cobalt(iimentioning

confidence: 99%

Synthesis and characterization of a hydrazone ligand containing antipyrine and its transition metal complexes

Fouda

Abd-Elzaher

Shakdofa

et al. 2008

Journal of Coordination Chemistry

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“…In the case of the present iron(III) complex, the 6 A 1 ground state is spilt into three Kramer doublets due to spin orbit mixing with excited states. These doublets are split by an applied magnetic field, and the near isotropic g-factor of 4.1 is assigned to a transition within one of them [47].…”

Section: Electron Spin Resonance Spectramentioning

confidence: 99%

Synthesis and characterization of transition metal complexes of N′-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)methylene]thiophene-2-carbohydrazide

Fouda

Abd-Elzaher

Shakdofa

et al. 2007

Transition Met Chem

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A hydrazone ligand (HL) containing the thiophene moiety has been prepared via condensation of thiophene-2-carbohydrazide with 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carbaldehyde. The complexes of copper(II), nickel(II), cobalt(II), manganese(II), zinc(II), palladium(II), iron(III), ruthenium(III), uranyl(VI), and titanium(IV) with the ligand were prepared in good yield from the reaction of the ligand with the corresponding metal salts. The ligand and complexes were characterized using infrared, mass spectra, nuclear magnetic resonance, electronic absorption spectra, electron spin resonance, and magnetic moment measurements as well as elemental and thermal analyses. The results showed that the complexes are enolic by nature, whilst the ratio between the metal ion and the ligand depends on the acidity of the metallic ions and their oxidation numbers.

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“…The FT‐IR spectrum of free Pip drug does not have a ν(C═O) COOH stretching vibration at ca 1700 cm −1 , because the carboxyl group is deprotonated and present in a zwitterionic state . Other bands appear at 2935 and 1631 cm −1 , which are assigned to ν(NH) piperazyl and ν(C═O) pyridone , respectively.…”

Section: Resultsmentioning

confidence: 99%

Study of the chemical structure and the microbial effect of iron(III) metal ions with four consecutive generations of quinolones in a nanometric form for the purpose of increasing the efficacy of antibacterial and antifungal drugs

Refat

El‐Sayed

Hassan

2018

Applied Organom Chemis

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A new series of iron(III) complexes with different fourth generation of quinolone drugs of the type [Fe(L)n(Cl)x]⋅yH2O ((1) L: nalidixic acid, n = 3, x = 3, y = 3; (2) L: oxolonic acid, n = 3, x = 3, y = 0; (3) L: pipemidic acid, n = 3, x = 3, y = 2; (4) L: lomefloxacin, n = 3, x = 3, y = 0; (5) L: pefloxacin mesylate, n = 3, x = 3, y = 2; (6) L: levofloxacin, n = 3, x = 3, y = 6) were synthesized and identified using microanalysis, Fourier transform infrared spectroscopy, conductance data, effective magnetic moments and electronic UV–visible spectra. In these six complexes, the quinolone drug chelates act in a unidentate manner via nitrogen atom of pyridone/piperazyl moiety. Electronic spectroscopic data are in agreement with an octahedral geometrical structure. Thermal degradation analyses in nitrogen gas were used to investigate the number and location of water molecules. The thermal decomposition process is completed in 3−5 steps, the first step being responsible for loss of uncoordinated water molecules and the steady state of all complexes occurs at around 500 °C with oxide forms as residual products. The stabilities of iron(III) complexes 1–6 were studied in terms of activation energy E*, entropy ΔS*, enthalpy ΔH* and Gibbs free energy ΔG* that were estimated using Coats–Redfern and Horowitz–Metzger non‐isothermal methods. Molecular docking was used to predict the binding between some of the quinolone drugs and the receptor of prostate cancer 2q7k hormone.

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Synthesis and spectroscopic studies of iron (III) complex with a quinolone family member (pipemidic acid)

Cited by 24 publications

References 31 publications

Synthesis and characterization of a hydrazone ligand containing antipyrine and its transition metal complexes

Synthesis and characterization of a hydrazone ligand containing antipyrine and its transition metal complexes

Synthesis and characterization of transition metal complexes of N′-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)methylene]thiophene-2-carbohydrazide

Study of the chemical structure and the microbial effect of iron(III) metal ions with four consecutive generations of quinolones in a nanometric form for the purpose of increasing the efficacy of antibacterial and antifungal drugs

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