Synthesis and stereochemistry of 5-substituted quinuclidine-2-carboxylic acids with semicyclic double bonds

Yakhontov, L. N.; Mastafanova, L. I.; Turchin, K. F.; Pervacheva, T. D.; Rubtsov, M. V.

doi:10.1007/bf00481043

Search citation statements

Order By: Relevance

Paper Sections

Select...

Results1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2005

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was obtained by base neutralization of the commercially available hydrochloride salt of the ketone 11, followed by Wittig olefination using methyltriphenylphosphonium bromide (Scheme 2). Initially, the alkene 12 was synthesized using sodium amide as the base, 13 but better yields were obtained using n-butyllithium.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of spiroisoxazolines through cycloadditions of nitrile oxides with 3-methylenequinuclidine

Lee¹,

Easton²,

Savage³

et al. 2005

Arkivoc

View full text Add to dashboard Cite

This paper is dedicated to Professor James M. Coxon (Jim) on the occasion of his 65 th birthday, and in recognition of his many contributions to chemistry Abstract Four spiroisoxazolines have been prepared, by cycloaddition of aceto-, pivalo-, benzo-and mesito-nitrile oxide with 3-methylenequinuclidine. The reactions were completely regioselective, within the limits of detection. None of the isoxazolines showed significant inhibition of acetylcholinesterase.

show abstract

Section: Resultsmentioning

confidence: 99%