Synthesis and stereochemistry of ?-azolylalkenes [1]

Ding, Ming‐Wu; Xiao, Wen‐Jing; Lu, Shuaicheng; Wen-fang, Huang; Shi, De‐Qing; Wu, Tianjie

doi:10.1002/(sici)1098-1071(1997)8:2<191::aid-hc12>3.0.co;2-m

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Scope Of Trifluoromethylation Reaction Of Methyl Fluorosulfo1

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1997

2023

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Cited by 6 publications

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“…In 2003, Ding and Huang were interested in the synthesis of β‐trifluoromethylenol phosphates for use as potential insecticides . The authors first attempted to synthesise these compounds through phosphorylation of the enolates of α‐trifluoromethylated ketones.…”

Section: Scope Of Trifluoromethylation Reaction Of Methyl Fluorosulfomentioning

confidence: 99%

Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation

Clarke

McGlacken

2016

Chemistry A European J

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The introduction of fluorine groups to pharmaceutical compounds can have a dramatic effect on the lipophilicity and metabolic stability of the molecule in vivo. Around 20 % of drugs contain at least one fluorine atom. The trifluoromethyl group is known to have beneficial effects and can dramatically affect the biological activity when substituted for a methyl group, for example. In any case, the direct and late-stage introduction of a trifluoromethyl group is a powerful transformation in the tool box of the medicinal chemist. The use of methyl fluorosulfonyldifluoroacetate (MFSDA) as a relatively inexpensive reagent for trifluoromethylation was first reported in 1989; however, in our opinion it has been somewhat underutilised. Herein, a comprehensive review of trifluoromethylation using MFSDA is reported, which we hope will further expose readers to this useful reagent.

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Section: Scope Of Trifluoromethylation Reaction Of Methyl Fluorosulfomentioning

confidence: 99%