Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones

Abstract

This review focuses on the synthesis of 3-hydroxyisoindolinones, and their application as substrates in stereoselective catalytic transformations reported from 2010 to date. These compounds have attracted much attention among synthethic...

Electrochemical 5-exo-dig aza-cyclization of 2-alkynylbenzamides toward 3-hydroxyisoindolinone derivatives

“…1). 1 To this end, state-of-the-art syntheses of 3-functionalized isoindolinones have been achieved via transition-metal catalysis, 2 electrosynthesis, 3 and photosynthesis. 4 Despite these advances, development of green and sustainable synthetic protocols toward the straightforward synthesis of these compounds is still in high demand.…”

Enantioselective intramolecular Pictet–Spengler type annulation of indole-linked 3-methyleneisoindolin-1-ones

“…Chiral isoindolinones are also crucial building blocks for a large number of natural products and bioactive compounds. 7,8 Therefore, asymmetric synthesis of chiral isoindolinones has attracted much attention and many strategies for the construction of chiral isoindolinones have been developed successfully. 9 Recently, research on the synthesis of isoindolinone fused tetrahydro β-carbolines was also reported.…”

Chiral Brønsted Acid Catalyzed Enantioselective Synthesis of Spiro-Isoindolinone-Indolines via Formal [3 + 2] Cycloaddition

“…In the literature, 3-hydroxyisoindolinones have been widely used for the enantioselective synthesis of mono- and disubstituted isoindolinones (at the C3 position) . But only a few reports are available to synthesize chiral spiro ring at the 3-position of isoindolinones (Scheme ).…”