Synthesis and structure–activity relationship of a pyrimido[4,5-d]pyrimidine derivative with antidepressant activity

Synthesis of novel pyrimidine and fused pyrimidine derivatives

“…Herein, when compound 2 was refluxed with the same reagent in boiling pyridine afforded the sulfur free product with molecular formula C19H15N7O [M .+ = 357] which detected as 7-amino-5-(4-methoxyphenyl)-3-(phenylamino)- [1,2,4]triazolo [4,3-a]pyrimidine-6-carbonitrile (11) (Scheme 5).…”

“…The recent wide applications of pyrimidine derivatives as anti-tumor [1], anti-HIV-1 [2], analgesic [3], anti-depressive [4], anti-convulsant [5], anti-microbial [6], herbicides [7,8], antiinflammatory and antioxidant [3,9], beside their uses as a precursors in the synthesis of fused ring compounds like, triazolopyrimidines as antibacterial agents [10], fungicidal [11], and anti-tumor agents [12], imidazopyrimidines as antimycobacterial [13] and pyridopyrimidines as antibacterial agents [14] make them worthy to be synthesized and evaluated as drugs. We report here synthesis of pyrimidine and fused pyrimidines by developed, simple, convenient and efficient procedure.…”

In SilicoMolecular Docking andIn VitroAntidiabetic Studies of Dihydropyrimido[4,5-a]acridin-2-amines

“…In recent years researchers are much interested in the synthesis of pyrimidine analogues. Pyrimidine derivatives posse fungicidal [1], herbicidal [2], antidepressant [3], and antitumor properties [4, 5]. Synthetically prepared amino pyrimidine derivatives display a wide range of biological activities such as antibacterial [6], antitumor [7], and antiviral [8, 9].…”

Hydroxyalkylation of 6‐aminouracil

“…3,4 6-AU and its alkyl-, aryl-, and hydroxyalkyl-derivatives are semiproducts in the synthesis of drugs used for heart diseases, [5][6][7][8] asthma, 9,10 tumor, [11][12][13] allergy, 14,15 and depression. 16 Hydroxyalkyl derivatives of 6-AU can be prepared in the reaction of cyanoacetic acid with N-(2-hydroxyethyl)urea (1-or 3-substituted derivatives) 6 and in the reaction of 6-chlorouracil, or 6-AU, or their 1,3-dialkyl derivatives with aminoalcohols, e.g., 2-aminoethanol or 3-aminopropanol (substituted derivatives at N atom of amine group). 7,[17][18][19][20][21] In this work, the possibilities of synthesis of hydroxyalkyl derivatives of 6-AU in the reactions of 6-AU with formaldehyde, oxiranes, and ethylene carbonate are presented.…”