Synthesis and structure–activity relationships of 2-(substituted phenyl)-3-[3-(N,N-dimethylamino)propyl]-1,3-thiazolidin-4-ones acting as H1-histamine antagonists

Synthesis of Novel Highly Functionalized 4-Thiazolidinone Derivatives from 4-Phenyl-3-thiosemicarbazones

“…Thiosemicarbazones have been used as intermediates for a great variety of heterocyclic products, such OPEN ACCESS as thiazolidinones, thiohydantoins, thioxopyrimidinediones. It is reported that thiazolidinones exhibit antibacterial [9], antifungal [10], anticonvulsant [11], antitubercular [12], anti-inflammatory [13], antihistaminic [14,15], cardiovascular [16] and anti-HIV [17] activities. As part of our research program on new bioactive compounds [18][19][20][21][22], we report herein an efficient synthesis of some new highly functionalized thiazolidinones derived from 4-phenyl-3-thiosemicarbazones.…”

Synthesis, Nematicidal and Antimicrobial Activity of 3-(5-3-Methyl-5-[(3-methyl-7-5-[2-(aryl)-4-oxo-1,3-thiazolan-3-yl]-1,3,4-thiadiazol-2-ylbenzo[<i>b</i>]furan-5-yl)methyl]benzo[<i>b</i>]furan-7-yl-1,3,4-thiadiazol-2-yl)-2-(aryl)-1,3-thiazolan-4-one

“…Thiazolidine-4-one derivatives are known to exhibit diverse bioactivities such as anti-convulsant, 17) antidiarrheal, 18) antiplatelet activating factor, [19][20][21] anti-histaminic, 22,23) antimicrobial, 24,25) anti-diabetic, 26) cyclooxygenase (COX) inhibitory, 27) Ca 2ϩ -channel blocker, 28) platelet activating factor (PAF) antagonist, 29) cardioprotective, 30) anti-ischemic, 31) anticancer, 32) tumour necrosis factor-a antagonist 33) and nematicidal activities. 34) Nematodes are tiny worms, some of them are plant parasites and can play an important role in the predisposition of the host plant to the invasion by secondary pathogens.…”

Synthesis and Antimicrobial Activity of Bis-[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]-thiadiazin-3-yl)phenyl]methanes and Bis-[(triazolo[3,4-b]thiadiazipin-3-yl)phenyl]methanes

“…[16][17][18][19][20][21] In addition, it was reported that triazole fused with a six-membered ring system is also found to possess diverse applications in the field of medicine. [22][23][24][25] The commonly known systems are triazolo-pyridines, 26 triazolo-pyridazines, 27 triazolo-pyrimidines, 28 triazolo-triazines, 29 triazolo-pyrazines, 30 triazolo-triazenes, 31 a few monomeric triazolo-thiadiazine, 31 and triazolo-thiadiazepines, 32 although there are not many triazoles fused to thiadiazines and thiadiazepines, there is a number of them that are incorporated into a wide variety of therapeutically important compounds possessing a broad spectrum of biological activities. [33][34][35][36][37] In recent years attention has been increasingly paid to the synthesis of bis-heterocyclic compounds which exhibit various biological activities, [38][39][40][41] including antibacterial, fungicidal, tuberculostatic and plant-growth regulating properties.…”