Synthesis and structure–activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives as potential agents against A549 lung cancer cells

Crystal structure of methyl 1-(4-fluorobenzyl)-3-phenyl-1H-pyrazole-5-carboxylate, C18H15FN2O2

“…Pyrazoles were also found to possess inhibitory activities against xanthine oxidase, cyclooxygenase, and alkaline phosphatases [5][6][7]. Particular substituents at the pyrazole provide additional biological activities [8,9]. In the title crystal structure, all bond lengths and angles are within normal ranges.…”

Microwave-Assisted Synthesis and Cytotoxicity Evaluation of Some Novel Pyrazole Containing Imidiazole, Pyrazole, Oxazole, Thiadiazole and Benzochromene derivatives

“…Recently, pyrazole derivatives have attracted a great attention due to their several chemicals and pharmacological importance [1][2][3]. Moreover, many pyrazole derivatives exhibit a wide range of therapeutic activities including anticonvulsant [4], analgesic, anti-inflammatory [5][6][7], antimicrobial [8], anticoagulant activity [9], antioxidant [10], antiamoebic [11,12], Antidepressant [13], antihyperglycemic [14], antihistaminic [15], anti-viral [16], anti-HIV [17], and anticancer [18][19][20][21][22]. (Fig.…”

Synthesis and preliminary mechanistic evaluation of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid amides with potent antiproliferative activity on human cancer cell lines

“…Among the reported studies, 4-quinolinylpyrazoles, 4-quinolinylimidazoles, 4-quinoxalinylpyrazoles and 4-( [1,2,4]triazolo [1,5-a]pyridin-6-yl)pyrazoles showed promising antiproliferative properties by inhibiting transforming growth factor-b type 1 receptor kinase, also known as activin receptor-like kinase 5 (ALK5) [12e15]. Moreover, pyrazole-5-carboxylate [10,16], pyrazole-5-carboxamide [4] and pyrazole-5-carbohydrazide [6,8,9,11] derivatives were also shown to have a significant anticancer activity against A549 lung cancer cell lines by inducing apoptosis or autophagy. Therefore, a wide range of information provided in the literature presents an ample opportunity for further investigation of pyrazole derivatives for the discovery of novel anticancer therapeutics.…”