Synthesis and Structure of Quaternary Phosphonium Salts Based on Phosphorylated Sterically Hindered Phenols

Atom Economical QPCs: Phenyl-Free Biscationic Quaternary Phosphonium Compounds as Potent Disinfectants

“…Along these lines, our groups have systematically evaluated a variety of QAC structural motifs to identify molecular features that can inform the rational design of new classes of disinfectants; we have recently advanced to machine learning techniques to predict the bioactivity of proposed compounds . Despite the development of over 700 different compounds by our groups in the past decade, concerns remain about the cross-resistance in AMR mechanisms between established QACs such as BAC into any novel QAC. , Accordingly, exploration of molecules with markedly different cationic amphiphilic heads, such as quaternary phosphonium compounds (QPCs) − and trivalent sulfonium compounds (TSCs), − are being pursued. Investigation into alternative amphiphiles resulted in the discovery of highly effective novel biscationic QPC compounds, highlighted by a structure termed P6P-10,10; for clarity within this paper, it will be labeled hereafter as Ph P6P-10,10 (Figure ).…”